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Articles by Xiaolin Yang
Human testis-specific TTRP regulates circadian clock as an evolutionarily young natural antisense transcript of PER2
Abstract The circadian clock orchestrates a variety of physiological and behavioral processes, endowing the ability to adapt to the cycling environment. Here, we report the identification of TTRP, a TDP-43 pseudogene that emerged in higher Hominoidea species ~8.6 Mya. TTRP is a human testis-specific gene that overlaps with the clock gene PER2 and interferes with PER2 transcription.
A potent EF1A promoter and a minimal U6 promoter enable highly efficient CRISPR genome editing in Aedes aegypti
Introduction The yellow fever mosquito, Aedes aegypti (Ae. aegypti), is a major vector for pathogens such as dengue and Zika viruses and, owing to its considerable biomedical importance, has emerged as a key model organism in vector control research (Kraemer et al., 2019; Rakotonirina et al., 2023; Crawford et al., 2025).
Microstructure evolution mechanism of the polycrystalline Mg_3Al_1Zn alloy under shock loading
Abstract The relationship between the microstructural evolution mechanisms and the dynamic performance characteristics of polycrystalline Mg-3Al-1Zn alloy under high-speed impact loading has not been fully elucidated, necessitating further research. Here, molecular dynamics (MD) simulations were used to systematically explore the shock-induced microstructural evolution mechanism of the Mg-3Al-1Zn alloy.
Genome-Wide Association Study of Lean Body Mass Response to Resistance Training in Young Asians
1 Introduction Bones and muscles are important components in humans, essential for movement and metabolism [1]. Increasing lean body mass is important for health, athletic performance and preventing chronic diseases such as diabetes, sarcopenia, and osteoporosis [2]. Physical activity has long been recommended to enhance fitness and health; in particular, ACSM recommended resistance training to enhance muscle strength, power and muscle hypertrophy [3].
Placebo response on the weight change and its influencing factors in overweight or obesity with or without diabetes: a meta-analysis of 182 anti-obesity medications trials
Abstract To further determine the placebo response and the associated factors in trials of anti-obesity medications (AOMs). PubMed, EMBASE, the Cochrane Center Register of Controlled Trials, and Clinicaltrial.gov website were searched from the inception to December 2025 for placebo-controlled trials of AOMs conducted in patients with overweight or obesity with or without diabetes. Overall, 182 trials were included.
Distributionally robust optimization dispatch strategy for virtual power plants based on data generation augmentation
Abstract The newly constructed renewable energy-oriented virtual power plants (VPPs) suffer from a scarcity of operation data for renewable energy and the uncertainties from both generation and load, which severely impact on the reliable operation and economic dispatch of VPPs. To address this issue, this paper proposes a distributionally robust optimization (DRO) scheduling strategy for VPPs based on data generation augmentation.
Comprehensive eco-geo-environmental assessment of the Sichuan–Yunnan ecological barrier zone using a random forest model
Abstract To address the contradiction among “high-intensity development, high ecological value, and high geological risk” in the Sichuan–Yunnan Ecological Barrier Zone, this study constructs an integrated assessment framework that incorporates geological, ecological, and human activity dimensions, in response to limitations of existing evaluation systems such as subjective weighting, inadequate characterization of ecological functions, and weak spatial integration.
Ru(bpy)32+‐DBAE Coreactant‐SDS Enhancer Systems on Automated Electrochemiluminescence Immunoassay Analyzer Containing Pt Electrode for Highly Sensitive Detection of Carbohydrate Antigen 19‐9
1 Introduction Pancreatic cancer is one of the most lethal malignancies, with its annual incidence rate closely mirroring its mortality rate. Carbohydrate antigen 19-9 (CA19-9) is a glycoprotein that serves as a key biomarker for pancreatic cancer diagnosis [1].
Magnetic Rolling Circle Amplification-Assisted Automated Electrochemiluminescence Immunoassay for Ultrasensitive Determination of Protein Biomarkers
Cite Jump to ExpandCollapse ArticleDecember 20, 2025 Magnetic Rolling Circle Amplification-Assisted Automated Electrochemiluminescence Immunoassay for Ultrasensitive Determination of Protein Biomarkers Click to copy article linkArticle link copied! Danyang Zhang Danyang Zhang Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, P. R.
Development and Validation of a Nomogram Model for Assessing the Impact of Continuous Lumbar Drainage Volume on Prognosis in Patients with Acute Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage
Introduction Subarachnoid hemorrhage (SAH) accounts for 5% of stroke cases, and aneurysm rupture is the underlying cause in 85% of SAH cases. Hydrocephalus is a major complication among patients with spontaneous SAH.1–3 Hydrocephalus can lead to a prolonged hospital stay, an increased number of days (d) in the intensive care unit (ICU), and an increased rate of shunt-dependent hydrocephalus in SAH patients.4 It is also a common cause of readmission after aneurysmal subarachnoid hemorrhage (aSAH).
Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis - Nature Communications
Abstract The MmpL5/MmpS5 efflux system in Mycobacterium tuberculosis plays crucial roles in extruding therapeutic drugs (e.g., bedaquiline), and exporting siderophores (i.e., (carboxy)mycobactins). However, the molecular basis underlying these processes remains unknown due to the lack of structural information. Here, we report the cryo-electron microscopy structures of Mycobacterium tuberculosis MmpL5/MmpS5 at resolutions ranging from 2.64 to 3.31 Å, revealing it to be a trimer.
Regulatory mechanisms of nitrogen homeostasis in insect growth and development
References , , , , , et al. (2017) In vivo isotopic labeling of symbiotic bacteria involved in cellulose degradation and nitrogen recycling within the gut of the forest cockchafer (Melolontha hippocastani). Frontiers in Microbiology, 8, 1970. , , , , , et al. (2015) Tritrophic interactions between parasitoids and cereal aphids are mediated by nitrogen fertilizer. Insect Science, 22, 813–820. , and (2020) What do we know about biological nitrogen fixation in insects?
Functional characteristics of pheromone binding proteins from Mythimna separata
Supporting Information Filename Description ins70029-sup-0001-SuppMat.docx2.3 MB Table S1 List of primers. Fig. S1 Sodium dodecyl sulfate – polyacrylamide gel electrophoresis analyses of expression tests of the target protein. Fig. S2 Sodium dodecyl sulfate – polyacrylamide gel electrophoresis analyses of purification test of Mythimna separata pheromone binding protein 1 (MsepPBP1). Fig.
Tomography Electrogenerated Chemiluminescence Imaging from Magnetic Microbeads
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202500804-sup-0001-SuppMat.docx4.5 MB Supporting Information References 1, , , J. Am. Chem. Soc. 2002, 124, 14478. 2, , Anal. Chem. 2020, 92, 524. 3, , , , Anal. Chem. 2020, 92, 431. 4, , , Chem. Commun. 2023, 59, 3507. 5, , , , , Small 2024, 20, 2307701. 6, Analytical Electrogenerated Chemiluminescence: From Fundamentals to Bioassays, (RSC) Publishing, Cambridge, 2020. 7, , , , , , , , , Chem. Sci.
Sustainable Management and Regulation of Agricultural Water Resources in the Context of Global Climate Change
Water is the lifeblood of agriculture, a sector that sustains global food security and livelihoods. However, the increasing complexity of water management in agriculture, exacerbated by global climate change, poses significant challenges to the sustainability of this vital resource. Specifically, climate change has intensified the risks associated with agricultural water management, particularly in regions already grappling with water scarcity [].
Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
ABCA1 ATP-binding cassette transport A1 ABCG1 ATP-binding cassette transport A1 G1 ACAT1 acetyl-CoA acyltransferase-1 ACC Acetyl-Coenzyme A carboxylase ANT2 ADP/ATP translocase 2 ATF3 activating transcription factor 3 C1QTNF1 C1q tumour necrosis factor-regulated protein 1 CETP cholesterol ester transfer protein CIC citrate carrier CPT carnitine palmitoyltransferase CPT1 and CPT2 carnitine palmitoyl transferases 1 and 2 CRR2 chemokine (C-C motif) receptor 2 FAO fatty acid oxidation FoxO1...
Sports-Related Genomic Predictors Are Associated with Athlete Status in Chinese Sprint/Power Athletes
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Genome-wide association study of exercise-induced skeletal muscle hypertrophy and the construction of predictive model
The relationship between appendicular skeletal muscle mass and all-cause mortality exhibits a J-shaped pattern (1). Elevated appendicular skeletal muscle mass index is associated with a reduced risk of cardiovascular disease (CVD) in young adults (20–39 yr) (2). The rate of muscle loss approximates 0.47% of peak mass per year in men and 0.37% per year in women (3).
Lateral homojunction of WSe2 through contact surface engineering with SF6 plasma etching
Lateral homojunction of WSe2 through contact surface engineering with SF6 plasma etching Here we report a simple contact surface pre-treatment, i.e. SF6 plasma dry-etching, to achieve efficient n-doping in CVD-grown two-dimensional multilayer WSe2 nanosheets as well as to build lateral p-n homojunctions with single-metal Nb contacts. The lateral homodiodes exhibit high rectification ratios over 104 and excellent photovoltaic properties with maximum open circuit voltage reaching up to 350-450 mV.
Study on the Long-Term Durability and Leaching Characteristics of Low-Consumption Cement Backfill under Different Environmental Conditions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dynamics of General Soliton and Rational Solutions in the (3 + 1)-Dimensional Nonlocal Mel’nikov Equation with Non-zero Background
Xiaolin Yang [1] ; Yi Zhang [1] ; Wenjing Li [1] [1] Zhejiang Normal University Localización: Qualitative theory of dynamical systems, ISSN 1575-5460, Vol. 23, Nº 5, 2024 Idioma: inglés Enlaces Texto completo Resumen Employing the KP reduction approach, the primary goal of this research work is to investigate the soliton and rational solutions of the (3 + 1)-dimensional nonlocal Mel’nikov equation with non-zero background. The solutions presented are all N × N Gram determinants.
Electrochemical Oxidative Thioetherification of Aldehyde Hydrazones with Thiophenols
Electrochemical Oxidative Thioetherification of Aldehyde Hydrazones with Thiophenols Electrochemical promoted oxidative dehydrogenation cross-coupling reaction between aldehyde hydrazones with thiophenols is demonstrated for the first time, which resulted in a variety of (Z)-thioetherified products in moderate to excellent yields. This strategy can be carried out under air atmosphere, featuring scalability and excellent stereoselectivity.
Turn-on fluorescent aptasensing for the determination of serotonin via target-induced knot displacement at corona
Turn-on fluorescent aptasensing for the determination of serotonin via target-induced knot displacement at corona† A turn-on fluorescence aptasensing approach for the highly sensitive and selective determination of 5-HT was proposed via target-induced knot displacement. 5-HT can be determined in a range from 0.5 nM to 100 nM with a limit of detection as low as 0.1 nM and a low dissociation constant of 2.3 nM. You have access to this article This article has not yet been cited.
An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality - Nature Structural & Molecular Biology
Abstract Oligopeptide permease, OppABCD, belongs to the type I ABC transporter family. Its role is to import oligopeptides into bacteria for nutrient uptake and to modulate the host immune response. OppABCD consists of a cluster C substrate-binding protein (SBP), OppA, membrane-spanning OppB and OppC subunits, and an ATPase, OppD, that contains two nucleotide-binding domains (NBDs).
An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality | Flipboard
5 hours ago Sign up for CNN’s Wonder Theory science newsletter. Explore the universe with news on fascinating discoveries, scientific advancements and more. CNN — Genetic analysis has shed light on a long-standing mystery surrounding the fates of President George Washington’s younger brother Samuel and his kin. …
Relationship between Sociodemographic and Health-Related Factors and Sedentary Time in Middle-Aged and Older Adults in Taiwan
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Diversifying crop rotation increases food production, reduces net greenhouse gas emissions and improves soil health - Nature Communications
Abstract Global food production faces challenges in balancing the need for increased yields with environmental sustainability. This study presents a six-year field experiment in the North China Plain, demonstrating the benefits of diversifying traditional cereal monoculture (wheat–maize) with cash crops (sweet potato) and legumes (peanut and soybean).
Effect of tumor exosome-derived Lnc RNA HOTAIR on the growth and metastasis of gastric cancer
Pan Chen [1] ; Zhenyang Liu [2] ; Hua Xiao [3] ; Xiaolin Yang [2] ; Ting Li [2] ; Wei Huang [4] ; Huijun Zhou [2] [1] The Animal Laboratory Center, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China [2] Department of Gastroenterology and Urology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, No. 283, Tongzipo Road, Changsha, 410013, Hunan,...
Disposable Capillary-fill Device for the Determination of Proteases Incorporating Eliminating Light-shield of Magnetic Beads with Cleavage of the Electrogenerated Chemiluminescence Label-tagged Peptide Probe
Disposable Capillary-fill Device for the Determination of Proteases Incorporating Eliminating Light-shield of Magnetic Beads with Cleavage of the Electrogenerated Chemiluminescence Label-tagged Peptide Probe A novel point-of-care test (POCT) method for the determination of proteases was developed for the first time using a designed disposable capillary-fill device incorporating eliminating light-shield of magnetic beads (MBs) with cleavage of electrogenerated chemiluminescence (ECL)...
The Blasting Vibration Characteristics of Layered Rock Mass under High-Pressure Gas Impact
1. Introduction Traditional explosive blasting technology has the characteristics of high efficiency and low cost, but only about 20–30% of its explosion energy is used to break rock mass in engineering applications [1]. And the remaining energy will inevitably produce some harmful effects on the surrounding environment, such as blasting vibration effect, air overpressure, flyrock, air pollution and backbreak [2].
High-efficiency gene editing in Anopheles sinensis using ReMOT control
Abstract CRISPR/Cas9-mediated gene editing provides an effective method for deciphering the molecular mechanisms underlying mosquito development and mosquito-borne disease transmission, as well as for exploring genetic control strategies. However, delivering the Cas9 ribonucleoprotein complex by embryo injection to produce genetic modifications is challenging, is mostly confined to model mosquitoes and specialized laboratories, and has low editing efficiency.
Micro X-ray fluorescence reveals pore space details and spatially-resolved porosity of rock-based microfluidic devices
Micro X-ray fluorescence reveals pore space details and spatially-resolved porosity of rock-based microfluidic devices Characterization of microscopic details of the fabric of mudstones and shales (i.e., structure and composition) is important to understand their storage and transport properties. Current characterization methods struggle to probe reliably multiple scales of interest (e.g., pore and fracture) and measure properties at the finest resolution under representative in situ conditions.
Elderly Residents’ Uses of and Preferences for Community Outdoor Spaces during Heat Periods
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by , , *, and College of Architecture and Urban Planning, Guangzhou University, Guangzhou 510006, China * Author to whom correspondence should be addressed.
Mechanism of Nozzle Position Affecting Coalbed Methane Mining in High-Pressure Air Blasting
Abstract : The use of clean energy is an important part of promoting sustainable energy development. As a clean energy source, coalbed methane, during the mining process, the position of the nozzle can influence coalbed methane extraction efficiency by affecting the cracking effect of coal. To investigate the impact of nozzles on the effect of coal fracture, a test of simulated coal by high-pressure air blasting was executed using nozzles 100 mm, 200 mm, and 250 mm from the orifice.
Improving the Energy Performance and Economic Benefits of Aged Residential Buildings by Retrofitting in Hot-Humid Regions of China
4. Results 4.1. Building Performance and Energy Cost before Retrofit The monthly energy performance and the corresponding cost of the residential building before retrofit are illustrated in Figure 6. The building′s energy demand was predominantly influenced by cooling needs due to the region′s hot and humid climate. The highest energy demand was observed in July, which is also the hottest month of the year, resulting in the maximum energy expenditure.
Longitudinal associations between parental and offspring’s leisure‐time physical activity: The Young Finns Study
ORIGINAL ARTICLE Xiaolin Yang, Corresponding Author xiaolin.yang@likes.fi LIKES Research Centre for Physical Activity and Health, Jyväskylä, Finland Correspondence Xiaolin Yang, LIKES Research Centre for Physical Activity and Health, Rautpohjankatu 8, 40700 Jyväskylä, Finland Email: xiaolin.yang@likes.fi Search for more papers by this author Tuomas Kukko, LIKES Research Centre for Physical Activity and Health, Jyväskylä, Finland Search for more papers by this author Mirja Hirvensalo, Faculty...
Ultrasound-assisted enzymatic extraction of Corni Fructus alpha-glucosidase inhibitors improve insulin-resistant in HepG2 cells
Ultrasound-assisted enzymatic extraction of Corni Fructus alpha-glucosidase inhibitors improve insulin-resistant in HepG2 cells Binkai Han, Haoqiang Sun, Xiaolin Yang, Ting Wang, Changfen He, Ke Zhao, Shujing An, Guo Chen, Dou Niu, Xiaochang Xue and Jiefang Kang Abstract Corni Fructus (CF) is a traditional medicine and beneficial food with multifaceted protective effects against diabetes and its complications.
Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo
Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo Huahong Yang, Cong Hua, Xiaolin Yang, Xiaoye Fan, Hongyu Song, Xinxin Ci and Liping Peng Abstract Early pulmonary fibrosis after acute lung injury leads to poor prognosis and high mortality. Pterostilbene (Pts), a bioactive component in blueberries, possesses anti-inflammatory, antioxidative and antifibrotic properties.
NLRP3 inflammasome and endoplasmic reticulum stress in the epileptogenic zone in temporal lobe epilepsy: molecular insights into their interdependence
ORIGINAL ARTICLE Chunqing Zhang Corresponding Author E-mail address: cqzhang@tmmu.edu.cn Epilepsy research center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, China Correspondence Chunqing Zhang, Department of Neurosurgery, Xinqiao Hospital, Army Medical University, 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China.
Study on thermal insulation of diagonal-braced wood frame wall
Study on thermal insulation of diagonal-braced wood frame wall Mingbin Liu, Feng Lu, Xiaolin Yang, Yang ruyuan bioRxiv 734178; doi: https://doi.org/10.1101/734178
Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target
References Adams P.D. Grosse-Kunstleve R.W. Hung L.W. Ioerger T.R. McCoy A.J. Moriarty N.W. Read R.J. Sacchettini J.C. Sauter N.K. Terwilliger T.C. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D Biol. Crystallogr. 2002; 58: 1948-1954 Ballell L. Bates R.H. Young R.J. Alvarez-Gomez D. Alvarez-Ruiz E. Barroso V. Blanco D. Crespo B. Escribano J. González R. et al. Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.
Long‐term determinants of changes in television viewing time in adults: Prospective analyses from the Young Finns Study
For men, inverse associations with initial levels of TV‐time were observed for students becoming employed and already has children, and direct associations were observed for both those who stayed a smoker and stayed overweight/obese. Increasing attention to health habits was inversely associated with a slope of TV‐time, whereas age and becoming unemployed were positively associated with the slope of TV‐time.
Correction: The quaternary lidocaine derivative QX-314 in combination with bupivacaine for long-lasting nerve block: Efficacy, toxicity, and the optimal formulation in rats
The model predictions were in reasonable agreement with the observations (A, B). Individual residuals were evenly distributed (C); and the weighted residuals were within ± 4 (D). The response-surfaces for sensory block (E) indicated that the duration of effective nerve blockade (Epred) prolonged as the concentration of QX-314 (X 1 ), but not bupivacaine (X 2 ), increased. The image for Fig 2 is incorrect. Please see the complete, correct Fig 2 here.
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