Xiaoying Ding
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Overweight/obesity accelerates proteinuria progression in type 2 diabetes post-COVID-19: a comparison with a pre-pandemic uninfected cohort
Abstract Aims: To assess whether overweight/obesity accelerates proteinuria progression in patients with type 2 diabetes mellitus (T2DM) after coronavirus disease 2019 (COVID-19) infection. Methods: This retrospective study included 688 patients with T2DM confirmed to have COVID-19 infection and 502 pre-pandemic uninfected patients with T2DM for comparative analysis.
COVID-19 associated CKM syndrome progression in diabetic patients is linked to pancreatic beta cell dysfunction, rather than RASi use: a retrospective cohort study
Abstract Background and aims: SARS-CoV-2 primarily has tissue tropism for the respiratory epithelium; however, it may cause multiple organ dysfunction due to the widespread expression of its entry receptor, ACE2. Specifically, SARS-CoV-2 may enter pancreatic β-cells by exploiting ACE2, disrupting cellular and hormonal activity, and thereby worsening Cardiovascular-Kidney-Metabolic (CKM) syndrome prognosis in diabetic patients.
Editorial: Novel strategies for the clinical management of cardiovascular-kidney-metabolic syndrome
The cardiovascular–kidney–metabolic (CKM) syndrome framework formalizes what clinicians have long observed: obesity, dysglycaemia, chronic kidney disease (CKD), and cardiovascular disease (CVD) are not parallel epidemics but intertwined disorders connected by shared pathobiology (insulin resistance, glucolipotoxicity, endothelial dysfunction, inflammation, oxidative stress, and maladaptive neurohormonal activation) that accelerate organ damage and premature death.
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