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Xiaoying Jian on Muck Rack

Xiaoying Jian

As seen in: BioRxiv, The Journal of Biological Chemistry, The Journal of Immunology
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Articles

Point mutations in Arf1 reveal cooperative effects of the N-terminal region and myristate for GTPase-activating protein catalytic activity

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By Eric Rosenberg, Xiaoying Jian, Olivier Soubias, R Andrew Byrd
| BioRxiv
Abstract The ADP-ribosylation factors (Arfs) constitute a family of small GTPases within the Ras superfamily, with a distinguishing structural feature of a hypervariable N-terminal extension of the G domain modified with myristate. Arf proteins, including Arf1, have roles in membrane trafficking and cytoskeletal dynamics.
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The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins

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By R. Andrew Byrd, Byrd R.A, Eric Rosenberg, Xiaoying Jian
| The Journal of Biological Chemistry Verified
One of the first reports suggesting the Arf pathway contributes to cancer progression was the finding that amplification of the gene ASAP1, which encodes an Arf GAP, correlated with metastasis in uveal melanoma ( 7 Ehlers J.P. Worley L. Onken M.D. Harbour J.W. DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma. ). Subsequently, ASAP1 amplification and/or expression was found to correlate with poor prognosis and metastasis in several carcinomas ( 8 Lin D.
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Abstract B32: ASAP1 regulates differentiation in myoblasts and PAX-FOXO1 fusion-negative rhabdomyosarcoma

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By Katie E. Hebron, Xiaoying Jian, Olivia Feehan-Nelson, Sofia A. Girald
| cancerres.aacrjournals.org
Poster Presentations - Proffered Abstracts Katie E. Hebron, Olivia Feehan-Nelson, Xiaoying Jian, Sofia A. Girald, Paul A. Randazzo and Marielle E. Yohe DOI: 10.1158/1538-7445.PEDCA19-B32 Published July 2020 Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada Abstract Rhabdomyosarcoma (RMS), the most frequently diagnosed soft-tissue sarcoma in children, is caused by a differentiation defect in skeletal muscle precursor cells.
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