Xiaoyong Yin

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Abstract Integrative genetic analysis of molecular and complex trait data, including colocalization analysis and transcriptome-wide association studies (TWAS), has shown promise in linking GWAS findings to putative causal genes (PCGs) underlying complex diseases. However, existing methods have notable limitations: TWAS tend to produce an excess of false-positive PCGs, while colocalization analysis often lacks sufficient statistical power, resulting in many false negatives.

Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 9 September 2024 / Approved: 10 September 2024 / Online: 10 September 2024 (05:48:58 CEST) Yin, X.; Tang, Y.; Yuan, L.; Ai, Y.; Tang, Y. Value Extraction and Integrated Utilization of Spatial Assets in Old Communities Regeneration: A Case Study of Central Guangzhou, China. Preprints 2024, 2024090746. https://doi.org/10.20944/preprints202409.0746.v1 Yin, X.; Tang, Y.; Yuan, L.; Ai, Y.; Tang, Y.