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Xiaozhe Yin on Muck Rack

Xiaozhe Yin

As seen in: Nature, MDPI, ACS Publications, Cell Reports
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Articles

Reactivating exhausted tumor-infiltrating T cells by a bispecific DC-T cell engager in mice

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By Xuhao Zhang, Yu Gao, Wenbo Hu, Yong Liang, Xiaozhe Yin, Xiangjun Shi, Hongjia Li, HuiPing Liao, Jingya Guo, Xiaohong Yu, Mingzhao Zhu, Hua Peng, Wenyan Wang, Yang-Xin Fu
| Nature Verified
Abstract Tumor infiltrating T cells (TIL) are key players in the anti-tumor immune response. However, chronic exposure to tumor-derived antigens drives the differentiation into ‘exhausted’ TILs. Whether intratumoral dendritic cells (DC) can mitigate TILs exhaustion and maintain function is unclear.
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Understanding Quasi-Static and Dynamic Characteristics of Organic Ferroelectric Field Effect Transistors

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By Hanjing Ke, Xiaoci Liang, Xiaozhe Yin, Baiquan Liu
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

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By Xiaozhe Yin, Wenfeng Zeng, Bowen Wu
| Cell Reports Verified
Highlights • Tumor-derived exosomes (TDEs) drive DC dysfunction • TDE-derived fatty acids activate PPARα to induce DC fatty acid oxidation • PPARα blockade modulates lipid metabolism and function in DCs • PPARα inhibition enhances the anti-tumor efficacy of immunotherapies Summary Dendritic cells (DCs) orchestrate the initiation, programming, and regulation of anti-tumor immune responses.
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