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Xiaqian Gong

As seen in: BioRxiv
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Articles

Sphingomyelins in mosquito saliva modify the host lipidome to enhance transmission of flaviviruses by promoting viral protein levels

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By Hacène Medkour, Lauryne Pruvost, Xiaqian Gong, Virginie Vaissayre
| BioRxiv
Abstract Mosquito saliva plays a determining role in flavivirus transmission. Here, we discover and elucidate how salivary lipids enhance transmission. Building upon our discovery of salivary extracellular vesicles (EV), we determined that lipids within mosquito EVs, and neither within human EVs nor virions, enhance infection for flaviviruses in primary cell types relevant for transmission.
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