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Hacène Medkour

As seen in: Nature, Wiley Online Library, BioRxiv, Cell Metabolism, HAL
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Articles

Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses

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By Hacène Medkour, Lauryne Pruvost, Elliott F. Miot, Xiaoqian Gong, Virginie Vaissayre, Mihra Tavadia, Pascal Boutinaud, Justine Revel, Atitaya Hitakarun, Wannapa Sornjai, Jim Zoladek, R. Duncan Smith, Sébastien Nisole, Justine Bertrand-Michel, Dorothée Missé, Guillaume Marti, Julien Pompon
| Cell Metabolism Verified
Keywords extracellular vesicles lipids dengue West Nile Zika Orthoflavivirus transmission bite unfolded protein response ERAD Introduction Several flaviviruses that cumulatively infect half a billion people annually, causing more than 120,000 fatalities and $9 billion in economic loss, are transmitted within mosquito saliva during biting.1 Nearly the entire human population is threatened by dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV), the most prevalent flaviviruses, due...
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Sphingomyelins in mosquito saliva modify the host lipidome to enhance transmission of flaviviruses by promoting viral protein levels

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By Hacène Medkour, Lauryne Pruvost, Elliott F. Miot, Xiaoqian Gong
| HAL
Pré-Publication, Document De Travail Année : 2024 Sphingomyelins in mosquito saliva modify the host lipidome to enhance transmission of flaviviruses by promoting viral protein levels Fichier principal 2024.06.14.599058v1.full.pdf (1.14 Mo) Télécharger le fichier hal-04917605 , version 1 (28-01-2025) Hacène Medkour, Lauryne Pruvost, Elliott F. Miot, Xiaoqian Gong, Virginie Vaissayre, et al..
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Sphingomyelins in mosquito saliva modify the host lipidome to enhance transmission of flaviviruses by promoting viral protein levels

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By Hacène Medkour, Lauryne Pruvost, Xiaqian Gong, Virginie Vaissayre
| BioRxiv
Abstract Mosquito saliva plays a determining role in flavivirus transmission. Here, we discover and elucidate how salivary lipids enhance transmission. Building upon our discovery of salivary extracellular vesicles (EV), we determined that lipids within mosquito EVs, and neither within human EVs nor virions, enhance infection for flaviviruses in primary cell types relevant for transmission.
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