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Xiayi Liao

As seen in: BioRxiv, Cell Press
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Articles

A Myosin Nanomotor Essential for Stereocilia Maintenance Expands the Etiology of Hereditary Hearing Loss DFNB3

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By Ghazaleh Behnammanesh, Abigail K Dragich, Xiayi Liao, Shadan Hadi
| BioRxiv
Abstract Cochlear hair cells transduce sound using stereocilia, and disruption to these delicate mechanosensors is a significant cause of hearing loss. Stereocilia architecture is dependent upon the nanomotor myosin 15. A short isoform (MYO15A-2) drives stereocilia development by delivering an elongation-promoting complex (EC) to stereocilia tips, and an alternatively spliced long isoform (MYO15A-1) tunes postnatal size in shorter stereocilia, which possess mechanosensitive ion channels.
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Select autosomal dominant DFNA11 deafness mutations activate Myo7A in epithelial cells

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By Prashun Acharya, Xiayi Liao, Samaneh Matoo, Gaima Thapa
| BioRxiv
Abstract Myosin-7A (Myo7A) is a motor protein crucial for the organization and function of stereocilia, specialized actin-rich protrusions on the surface of inner ear hair cells that mediate hearing. Mutations in Myo7A cause several forms of genetic hearing loss, including autosomal dominant DFNA11 deafness. Despite its importance, the structural elements of Myo7A that control its motor activity within cells are not well understood.
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Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin

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By Jamis McGrath, Indiana University-Purdue, Chun-Yu Tung, Xiayi Liao
| Cell Press Verified
Highlights • Mechanotransduction regulates actin at the tips of mammalian cochlear stereocilia • With transduction onset, ADF/cofilin localize to mechanotransducing stereocilia tips • Actin-severing proteins increase available F-actin barbed ends at stereocilia tips • Normal stereocilia length and width depend on ADF and cofilin-1 Summary Stereocilia on auditory sensory cells are actin-based protrusions that mechanotransduce sound into an electrical signal.
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