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Xidai Long

As seen in: Frontiers in Immunology
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Articles

Affinity and costimulatory architecture-associated toxicity in mesothelin-targeted TCR-mimetic CAR-T cells

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By Wei Du Verified, Siqi Li, Chen Wang, Rui Lu, Wenbin Yu, Jie Lin, Fang Tang, Enxiu Wang, Shaomei Gan, Xidai Long
| Frontiers in Immunology
Abstract Introduction: TCR-mimetic CAR-T combines antibody-based targeting with physiological TCR signaling, yet suboptimal co-stimulation and safety risks remain key barriers for solid tumor therapy. The prevailing assumption that stronger co-stimulation yields superior efficacy has not been systematically tested in TCR-mimetic CAR-T architectures.
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