Skip To Main Content
Xidi Yin on Muck Rack

Xidi Yin

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Xidi

Contact Xidi, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration

|
By Qing Li, Chuanyin Li, Li Guo, Yingyi Wang, Yanbo Cheng, Nan Liu, Qi Yin, Yifu Ding, Zihan Liu, Junyu Chen, Jin Zhang, Shuo Huang, Huanhuan Deng, Yuanyuan Li, Di Chen, Ian Chambers, Hui Zheng, Ronggui Hu, Man Zhang, Jinsong Li, Xidi Yin, Wangpeng Gu, Anjing Guo
| Nature Verified
Abstract During primordial germ cell (PGC) specification, repression of somatic programs is essential for the establishment of germline identity. However, mechanisms that safeguard PGC fate thereafter remain unknown. Here, we identify the E3 ubiquitin ligase TRIM37 as a critical safeguard of PGC fate during migration. Trim37 deficiency causes severe PGC defects beginning at embryonic day 9.5 (E9.5) with complete PGC depletion by E12.5, and leads to an aberrant transition toward somatic cell states.
Open in Who Shared Issue with article?
See all 1 articles