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Abstract Activated platelets contribute to inflammation in rheumatoid arthritis, but how platelet-derived signals promote bone erosion remains poorly understood. Here we show that thromboxane A2, a major mediator released by activated platelets, promotes the formation of bone-resorbing osteoclasts through the thromboxane A2 receptor.
Introduction Dental pulp is a kind of distinct connective tissue located in the central part of teeth, which is wrapped by dental hard tissues and consists of cells, fibers, lymphatic vessels, blood vessels and nerves. The pulp and dentin are jointly known as the pulpo-dentinal complex, because of they both develop from the dental papilla, and have closely relationships in anatomy and histophysiology.
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