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Xinyin Fu on Muck Rack

Xinyin Fu

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Articles

GPR124 promotes NLRP3 inflammasome activation through impaired mitochondrial autophagy homeostasis in ox-LDL-treated endothelial cells

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By Jie Qu, Yangyang Pang, Yiqian Xu, Qingyun Guo, Xingyue Fang, Yingmei Lu, Qingwen Meng, Qibing Liu, Xinyin Fu
| Nature Verified
Abstract G protein-coupled receptor 124 (GPR124) has been implicated in endothelial dysfunction, but its role in ox-LDL-induced endothelial inflammatory injury remains incompletely understood. This study investigated whether GPR124 contributes to endothelial cell injury through disruption of mitochondrial autophagy homeostasis and subsequent activation of the NLRP3 inflammasome.
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