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Yingmei Lu on Muck Rack

Yingmei Lu

As seen in: Nature, Wiley Online Library, Cell Press
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Articles

GPR124 promotes NLRP3 inflammasome activation through impaired mitochondrial autophagy homeostasis in ox-LDL-treated endothelial cells

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By Jie Qu, Yangyang Pang, Yiqian Xu, Qingyun Guo, Xingyue Fang, Yingmei Lu, Qingwen Meng, Qibing Liu, Xinyin Fu
| Nature Verified
Abstract G protein-coupled receptor 124 (GPR124) has been implicated in endothelial dysfunction, but its role in ox-LDL-induced endothelial inflammatory injury remains incompletely understood. This study investigated whether GPR124 contributes to endothelial cell injury through disruption of mitochondrial autophagy homeostasis and subsequent activation of the NLRP3 inflammasome.
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Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression - Nature Communications

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By Ryan C Gimple, Daqi Li, Linjie Zhao, Hui Yang, Wei Gao, Weiwei Tao, Yingmei Lu, Yun Chen, Jing Ji, Zhe Zhu, Chunsheng Kang, Jianghong Man, Sameer Agnihotri, Qianghu Wang, Xu Qian, Stephen Mack, Zhibin Hu, Chaojun Li, Michael Taylor, Nu Zhang, Ming Lu, Jeremy Rich, Wei Zhang
| Nature Verified
Abstract Glioblastoma (GBM) is the most lethal primary brain tumor with intra-tumoral hierarchy of glioblastoma stem cells (GSCs). The heterogeneity of GSCs within GBM inevitably leads to treatment resistance and tumor recurrence. Molecular mechanisms of different cellular state GSCs remain unclear. Here, we find that classical (CL) and mesenchymal (MES) GSCs are enriched in reactive immune region and high CL-MES signature informs poor prognosis in GBM.
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