Xinying Cheng

1 Introduction Myeloproliferative neoplasms are myeloid malignancies defined byhypercellular bone marrow and elevated peripheral blood cell counts [1]. The classical subtypes (Figure 1) include polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). MF can present asprimary myelofibrosis (PMF) or develop from a pre-existing MPN such as PV or ET, in which case it is referred to assecondary myelofibrosis (SMF) [2, 3].

Abstract Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic efficacy and severe side effects associated with conventional chemotherapy, creating an urgent need for safe and effective natural anti-tumor agents. Quercetagetin-rich marigold flavonoids (QG-MF), isolated from the lutein-extracted inflorescence residues of Tagetes erecta L.

Keywords Triple-negative breast cancer Adenosine-receptor signalling pathway Immunogenic cell death Tumor immune microenvironment Chemo-immunotherapy synergy Nanomedicines Evidence before this study EPI, a first-line chemotherapeutic agent for TNBC, has been extensively studied because it can directly kill tumor cells and induce ICD. Evidence indicates that EPI triggers ICD through high mobility group box 1 (HMGB1) release, calreticulin (CRT) exposure, and ATP secretion.