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Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction
Highlights • CRAD is reduced in colorectal tumorigenic cells responding to substrate rigidity • CRAD inhibits CRC stemness by regulating YAP transcriptional co-repressor activity • CRAD-dependent mechanical signaling dictates CRC metastasis • CRAD-F-actin-YAP axis regulates CRC progression in vivo Summary Tumor physical microenvironment contributes greatly to the response of tumor cells.
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