Xinying Zeng

Abstract Advancements in sequencing technology enable the investigation of genomic information within its three-dimensional (3D) spatial structure, offering new insights into genome organization and function. However, the role of higher-order chromatin architecture in species divergence and speciation remains largely unexplored.

Conflicts of Interest The authors declare no conflicts of interest. References , and . 2004. “Organizing Rent Generation and Appropriation: Toward a Theory of the Entrepreneurial Firm.” Journal of Business Venturing 19, no. 5: 621–635. , , and . 2013. “Forming and Exploiting Opportunities: The Implications of Discovery and Creation Processes for Entrepreneurial and Organizational Research.” Organization Science 24, no. 1: 301–317. , , and . 2015.

1 Introduction With the rapid advancement of industrialization, occupational lung diseases have become a growing global health concern. Among them, silica-induced pulmonary fibrosis is particularly severe, characterized by silicotic nodule formation and diffuse fibrosis driven by persistent fibroblast activation and excessive extracellular matrix (ECM) deposition (Baum and Arnold 2025; Sherekar et al. 2025; Wang et al. 2024).