Xinying Zhao

Abstract Background: We investigated differences in memory-guided saccades (MGS) and electroencephalographic (EEG) spectral ratios between cognitively normal older adults and patients with mild cognitive impairment (MCI). A multimodal predictive model was developed to evaluate its potential for early MCI identification. Methods: We enrolled 60 participants (37 MCI, 23 controls) who underwent cognitive assessments, 32-channel resting-state EEG, and MGS testing.

The optical skyrmion and its topological behavior are analyzed in an energy flux field constructed by an X-type vortex in a high numerical aperture system. The conditions for the formation of a skyrmion structure in this field are discussed, showing that the vortex pattern of the transverse energy flow and the inverse energy flow are crucial for the skyrmions and also are controlled by the phase gradient of the X-type vortex.

Abstract The Mediator complex regulates various aspects of hematopoietic development, but whether composition of the Mediator complex undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that MED26, a subunit in the core Mediator complex, played a distinctive role in facilitating transcription pausing essential for erythroid development. While most Mediator subunits drastically decreased during this process, MED26 remained relatively abundant.