Xiying Mao

1 Introduction Single-cell omics technologies, such as single-cell genome, epigenome, transcriptome, proteome, and metabolome, enable a deep depiction of the landscape of cellular molecular biological processes. They facilitate to describe the complete procedure of the “central dogma” and deconstructs the molecular interaction mechanism and targets from macromolecules (nucleic acids, proteins) to small molecules (metabolites), uncovering the nature of cellular heterogeneity.

Abstract Background Pathogenic variants of G-protein coupled receptor 143 (GPR143) gene often leads to ocular albinism type I (OA1) characterized by nystagmus, iris and fundus hypopigmentation, and foveal hypoplasia. In this study, we identified a novel hemizygous nonsense mutation in GPR143 that caused an atypical manifestation of OA1.

Highlights • Fate transition occurring in RPC is concomitant with onset of retinal neurogenesis • Molecular dynamics underlying RPC commitment are dissected • CCND1 promotes retinal neurogenesis in a cell-cycle-independent manner Summary The development of the mammalian retina is a complicated process involving the generation of distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific manner.