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Identification of the expression of tRNA-derived small RNAs associated with necrotizing enterocolitis
Abstract Necrotizing enterocolitis (NEC) is a severe neonatal gastrointestinal disease. We explored plasma exosomal small noncoding RNAs (sncRNAs), especially tsRNAs, as potential NEC treatment targets. Small RNA microarray analysis was performed on exosomes from 4 NEC and 4 control plasma samples, and 9 paired samples were used for qRT-PCR validation. GO and KEGG analyses determined tsRNAs’ functions, and TargetScan and miRanda identified their target genes.
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