Xueying Zhou
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Exploration of the regulatory mechanism of PD-L1 expression in pMMR AGS gastric cancer cell by cytotoxic drugs and anti-angiogenic drugs
Abstract Immune checkpoint inhibitors (ICIs) play a key role in treating advanced gastric cancer; however, their efficacy is limited in patients with proficient mismatch repair (pMMR) tumors. Therefore, enhancing ICIs sensitivity in this subgroup is crucial. Preclinical studies have indicated that cytotoxic and anti-angiogenic drugs may boost ICIs efficacy by modulating programmed death-ligand 1(PD-L1) expression via pathways such as PI3K/AKT and MAPK in other cancers.
Frontiers | Diphtheria-tetanus-acellular pertussis vaccine safety in children under 7 years: a post-marketing analysis of the U.S. vaccine adverse event reporting system
Introduction Pertussis incidence in the U.S. has significantly decreased since the adoption of tetanus, diphtheria toxoids, and whole-cell pertussis vaccines during the 1940s (Loiacono et al., 2021). Beginning in the 1990s, replacement occurred with acellular pertussis (DTaP) vaccines (Centers for Disease Control and Prevention, 1992a).
Site-Specific Capsid Modification Enables FRα-Directed Retargeting of AAV for Precision Gene Delivery
Molecular Pharmaceutics Cite this: Mol. Pharmaceutics 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
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