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Xuezhu Feng

As seen in: Nature, BioRxiv, Cell Press
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Articles

piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation - Nature Structural & Molecular Biology

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By Chengming Zhu, Ke Ruan, Ying Zhou, Ge Shan, Xiangyang Chen, ShengQi Xiang, Xinya Huang, Xuezhu Feng
| Nature Verified
Abstract Piwi-interacting RNAs (piRNAs) are essential for maintaining genome integrity and fertility in various organisms. In flies and nematodes, piRNA genes are encoded in heterochromatinized genomic clusters. The molecular mechanisms of piRNA transcription remain intriguing. Through small RNA sequencing and chromatin editing, we discovered that spatial aggregation of piRNA genes enhances their transcription in nematodes.
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Compartmentalized localization of perinuclear proteins within germ granules in C. elegans

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By Xiaona Huang, Xuezhu Feng, Yong-Hong Yan, Demin Xu, Ke Wang, Chengming Zhu, Meng-Qiu Dong, Xinya Huang, Shouhong Guang, Xiangyang Chen
| Cell Press Verified
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TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans

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By Kun Li, Xuezhu Feng, Ke Wang, Xiaona Huang
| BioRxiv
Abstract Germ granules are biomolecular condensates composed of RNA and proteins that play crucial roles in RNA metabolism and posttranscriptional gene regulation. C. elegans germ granules consist of at least seven distinct subcompartments, including P granules, Z granules, Mutator foci, SIMR foci, P-bodies, D granules and E granules.
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