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Xuhuang Tu

As seen in: Cell Press
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Articles

Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

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By Yuqi Zhou, Xiaohong Ye, Guobin Xie, Xuhuang Tu
| Cell Press Verified
Highlights • Cdk1 phosphorylation of RXRα induces its translocation to centrosome during mitosis • Centrosomal RXRα modulates mitosis by interacting with PLK1 • Cdk1-phosphorylated RXRα confers tumor cells with vulnerability to RXRα inhibitors • An RXRα ligand promotes mitotic catastrophe by inhibiting p-RXRα/PLK1 interaction Summary Retinoid X receptor alpha (RXRα), a nuclear receptor of transcription factor, controls various physiological and pathological pathways including cellular growth,...
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