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Articles by Xuling Chang
Tissue-specific genomics uncovers coregulators in telomere biology that affect risk of ischemic heart disease
Abstract Leukocyte telomere length (TL) attrition, a hallmark of cardiovascular aging, is a known risk factor for ischemic heart disease (IHD). However, the tissue-specific genetic dysregulation that affects telomere homeostasis and the mechanisms underlying their effects on IHD remain unclear. We performed a transcriptome-wide association study (TWAS) using gene expression data from eight different tissue types known to play a role in IHD, including arteries, adipose tissues, liver, and others.
Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization
Keywords DNA regulatory element transcription gut microbiome liver-gut axis functional genomics Introduction The hepatic transcriptome is highly responsive to nutritional and environmental cues, due to the unique anatomical connection between the gut and liver via the portal vein, which delivers nutrients, microbial metabolites, and endotoxins directly to hepatocytes.
Predictive capabilities of polygenic scores in an East-Asian population-based cohort: the Singapore Chinese health study - Communications Biology
Abstract Polygenic scores (PGS) are derived primarily from European population studies. It is unclear how these perform in risk predictions among East-Asians. We generated 2173 PGSs from 519 traits and assessed their associations with 58 baseline phenotypes in the Singapore Chinese Health Study, a prospective cohort of 23,622 Chinese adults residing in Singapore.
Common variants at 22q12.2 are associated with susceptibility to Tuberculosis
The authors have declared no competing interest. This work was supported by the National Health and Medical Research Council, Australia (Investigator grant APP1172853 to SJD); NHMRC (APP1056689) /A*STAR (12/1/21/24/6689) joint call to SJD/YYT; the USA National Institute of Health (U19AI162583 to SJD); This research was funded by Wellcome in whole, or in part (research training fellowship 081814/Z/06/Z to MC, 206724/Z/17/Z to NTTT and 089276/Z/09/Z to Major Overseas Program in Vietnam).
Disruption of Aldehyde Dehydrogenase 2 protects against 1 bacterial infection
Abstract The ALDH2*2 (rs671) allele is one of the most common genetic mutations in humans, yet the positive evolutionary selective pressure to maintain this mutation is unknown, despite its association with adverse health outcomes. ALDH2 is responsible for the detoxification of metabolically produced aldehydes, including lipid-peroxidation end products derived from inflammation.
Increased BMI and late-life mobility dysfunction; overlap of genetic effects in brain regions - International Journal of Obesity
Abstract Background How obesity earlier in life impacts upon mobility dysfunctions in late life is not well understood. Pernicious effects of excess weight on the musculoskeletal system and mobility dysfunctions are well-recognized. However, increasingly more data support the link of obesity to overall motor defects that are regulated in the brain.
Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population
Xuling Chang1,2 na1, Rajkumar Dorajoo3 na1, Ye Sun4, Ling Wang3, Choon Nam Ong5,6, Jianjun Liu3,7, Chiea Chuen Khor3,8, Jian-Min Yuan9,10, Woon Puay Koh5,11, Yechiel Friedlander12,13 & Chew-Kiat Heng1,2 Nutrition Journal volume 19, Article number: 119 (2020) Cite this article Abstract Background Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality.
Gene-diet interaction effects on BMI levels in the Singapore Chinese population
Ethnic differences in dietary intakes may influence the impact of inherent genetic predispositions to obesity. In this study, we evaluated the role of dietary intake, both as individual nutrient components and as a composite score (i.e AHEI-2010), on BMI levels using East-Asian subjects.
Utility of genetic and non-genetic risk factors in predicting coronary heart disease in Singaporean Chinese
Although numerous phenotype based equations for predicting risk of ‘hard’ coronary heart disease are available, data on the utility of genetic information for such risk prediction is lacking in Chinese populations. A total of 1306 subjects comprising 836 men (267 incident cases and 569 controls) and 470 women (128 incident cases and 342 controls) were included.
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