Xunzhong Qi on Muck Rack

Xunzhong Qi

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Articles

BDNF restores impaired long-term potentiation of GABAergic synapses induced by chronic ethanol exposure in the VTA and attenuates reward-seeking behavior

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By Ying Wang, Ting Zeng, Jia-Ning Wei, Dan-Dan Cui, Xiao-Fei Wang, Xiaofeng Zhu, Jun-Wei Xiong, Meng-Yao Dou, Xunzhong Qi, Xiao-Wei Shi, Hui-Zhen Dai, Chen-Yu Du, Xiang-Min Xu, Yanzhong Guan
| Nature Verified
Abstract Cellular and synaptic plasticity in ventral tegmental area (VTA) play a key role in alcohol use disorder (AUD). Here, we first delineated the in vivo dynamics of dopamine (DA) neuron activity in VTA during chronic intermittent ethanol exposure: initial sensitization was followed by a phase of attenuated and dysregulated response upon the first high-concentration exposure, culminating in stable hyper-responsiveness.
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