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Articles by Y. Ito
Recovery of terpenoids from Bixa orellana seeds via high performance- and high speed-countercurrent chromatography guided off-line atmospheric pressure chemical ionization mass spectrometry profiling
Seeds of Bixa orellana (Bixaceae) have a long tradition in the South-American culture as body- and hair colouring agent, insect repellent, sun-protection, spice and are even used as traditional medicine. e.g., for the treatment of jaundice, gonorrhoea and leprosy.
Tetrahydrocannabinol separation from cannabis extracts using centrifugal partition chromatography
Cannabis sativa L. belongs to the Cannabaceae family and is considered a monospecific plant. it is classified into different varieties that exhibit significant variability at the phenotypic, genotypic, and metabolic levels. These include drug-type varieties (cannabis sativa or just cannabis) and fiber-type varieties (hemp) mainly. Hemp contains significantly lower levels of cannabinoids [1].
Profiling of B-type procyanidins oxidation products by off-line high speed countercurrent chromatography x electrospray ionisation mass spectrometry flow-injection
Proanthocyanidins (PAs) are present in agro‑industrial waste due to their occurrence in the fruit pods, seeds, seed shells, and bark [1,2]. In 2022, approx. 1.05 billion tons of food waste were discarded worldwide [3], from which bioactive compounds could be extracted as part of the zero‑waste strategy [4]. Using by-products, to recover antioxidant polyphenols, for example, is important for a circular economy [5].
COUNTERCURRENT CHROMATOGRAPHY RESEARCH SHAPED BY YOICHIRO ITO
The 12th International Countercurrent Chromatography Meeting in Rio de Janeiro, July 2024, was the first one without the presence of Yoichiro Ito, the inimitable separation scientist whose life’s work touched scientists all around the world (Fig. 1). Here it is a privilege to review his long career of discovery and innovation in separation science. During World War II when he was young, Yoichiro Ito worked in a munitions factory where he picked up his mechanical skills.
Theoretical study of modified multiple dual-mode elution counter-current chromatography based on chiral separation
Chiral molecules have been extensively researched in the domains of biomedicine [1,2], natural product synthesis [3,4], and drug discovery [[5], [6], [7]] in recent years. The exceptional therapeutic efficacy and safety of chiral drug molecules are the primary factors contributing to this increased interest [8]. Chiral molecules typically differ in their optical characteristics due to their distinct stereochemical structures.
Integrated Strategy by Combining Preparative HSCCC with HPLC-UV-QDa for Efficient Isolation of Specific Friedelane-type Triterpenoids from Salix tetrasperma - ScienceDirect
Natural products play a vital role in innovative drug development due to their complex and diverse structural skeletons and significant biological activities. Considering the low content and particular physicochemical properties of some bioactive constituents in natural medicines, it is quite urgent to develop efficient and selective purification methods.
Recent development on stereoselective intramolecular O-glycosylation methodology
Anindra Sharma, born in Uttar Pradesh (in 1986) is associated with A. P. S. M. College, Barauni, Bihar as Assistant Professor of Chemistry since 2017. He earned his M.Sc. (Organic Chemistry in 2006) from U. P. College, Varanasi and then joined CSIR-Central Drug Research Institute, Lucknow (Mentor: Dr. R. P. Tripathi) as CSIR-JRF and awarded his Ph.D. degree in 2012 from Jawaharlal Nehru University, New Delhi. He had postdoctoral experience at Indian Institute of Science, Bangalore (Mentor: Prof. N.
A HPLC-assisted mathematical prediction method of ternary solvent systems to develop an intelligent online selection system for countercurrent chromatography solvent system
Countercurrent chromatography (CCC), a unique liquid-liquid partition chromatography technique, is widely used for the separation and purification of various active components from natural products due to its properties of no adsorptive sample loss, high recovery rate and high reproducibility [[1], [2], [3]]. An appropriate biphasic solvent system is the fundamental requirement for a successful CCC separation [4].
Tamaru reaction-based approach towards the synthesis of muscone and analogues using renewable sources
Musks are the most adaptable odorants used in perfumery. Muscone is one of the valuable compounds, a constituent of musk pod obtained from pouches of male deer Moschus moschiferus [1a]. (R)-Muscone has an odour threshold of 61 ppb and has a very pleasant musky, rich, and strong scent. On the other hand, the odour threshold of (S)-muscone is just 223 ppb, making it less fragrant [1b].
Improvement of polarity-based solvent system for countercurrent chromatography in the guidance of solvent selectivity: n-hexane/ethyl acetate/ alcohol solvents/water as an example
Countercurrent chromatography (CCC) is an efficient separation technique that avoids irreversible adsorption of solid stationary phase to the sample, allowing for flexible operation modes [1]. The CCC solvent system can consist of any chemical solvent that is insoluble in two phases, providing more options for separating complex natural samples [[2], [3], [4]].
Optimisation of isolation of polyphenols from Malus pumila Mill. Leaves by high-speed countercurrent chromatography using response surface methodology
Apple (Malus pumila Mill.), one of the highest economic fruits in the world, is widely consumed as dietary supplements for the whole year [1]. Some epidemiological studies have reported that regularly eating apples is conducive to the prevention of many diseases [2], [3]. These benefits are attributed to active ingredients in the apple, especially polyphenols.
Structure of Kα1,2- and Kβ1,3-emission x-ray spectra for Se, Y, and Zr
Article Dans Une Revue Physical Review A Année : 2020 Structure of Kα1,2- and Kβ1,3-emission x-ray spectra for Se, Y, and Zr Mots clés Radioactivity Ionizing radiation Spectrum analysis Spectrometry X-rays Double-crystal x-ray spectrometer Nuclear instrumentation Instrumentation Metrology Asymmetry index Spin doublet energy Peak position Peak width Fichier principal OpenAccess_YIto_PhysRevA.102.052820.pdf (3.04 Mo) Télécharger le fichier Origine : Fichiers éditeurs autorisés sur une archive...
Separation of Ochratoxins by Centrifugal Partition Chromatography
Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi [1]. Among them, ochratoxins (OTs) are of outstanding importance, due to their high-level toxicity, which could cause remarkable problems in the food and feed industry [2]. The most important member of this mycotoxin group is ochratoxin A (OTA), isolated and chemically characterised in 1965. The structure of OTA contains a dihydroisocoumarin moiety coupled to a L-ß-phenylalanine (Figure 1) [3].
Model-based design of gradient elution in liquid-liquid chromatography: application to the separation of cannabinoids
In liquid-liquid chromatography (LLC), two liquid phases originating from an equilibrated biphasic solvent system are used as stationary and mobile phases. The liquid stationary phase is kept inside an LLC column with the help of centrifugal force. Components of a mixture are separated due to their different partitioning between the two liquid phases, and they elute from the column according to their distribution constant (partition coefficient).
Multistep pH-peak-focusing liquid chromatography with a hydrophilic polymer gel column for separation of rare earth elements
Rare earth elements are used in many areas of modern technology as an essential part of various high technology devices and the demand for high-purity individual rare earth elements is increasing [1]. The main method currently used for the separation of rare earth elements in industry is liquid-liquid extraction using organic solvents and chelating reagents [2], [3], [4].
Application of Two-Dimensional Reversed Phase Countercurrent Chromatography × High-Performance Liquid Chromatography to Bioactivity-guided Screening and Isolation of α-Glucosidase Inhibitors from Rheum palmatum L. - ScienceDirect
Available online 19 January 2024, 464667 Application of Two-Dimensional Reversed Phase Countercurrent Chromatography × High-Performance Liquid Chromatography to Bioactivity-guided Screening and Isolation of α-Glucosidase Inhibitors from Rheum palmatum L.
Modeling of analytical, preparative and industrial scale counter-current chromatography separations
Liquid-liquid chromatography techniques [1], [2], [3], [4], [5], [6], [7], commonly known as countercurrent chromatography (CCC) [8], [9], [10], [11], [12], [13] and / or centrifugal partition chromatography (CPC) [14], [15], [16], [17], are based on centrifugal devices and primarily used for the analytical and preparative separations of natural products and pharmaceutical substances. [17], [18], [19], [20], [21], [22], [23], [24].
Purification and Characterization of pure curcumin, desmethoxycurcumin, and bisdemethoxycurcumin from North-East India Lakadong turmeric (Curcuma longa)
Ayurveda is the richest source of herbal medicine and copious products are at one's fingertip in the market with good efficacy. However, quality control is still a challenging task for herbal medicine due to the non-availability of certified herbal reference material and exorbitant cost of accessible reference materials as per contemporary analytical techniques. In general, the reference material should adhere with the ISO Guide 35:2017 [1].
Retention correlation and orthogonality between reversed phase countercurrent chromatography and liquid chromatography based on solvent strength
Natural products usually comprise a large number of compounds with different polarity so that study on composition of natural products is one of the most difficult task in pharmaceutical analysis [1,2]. It is usually difficult to achieve complete separation for natural product sample using conventional one-dimensional chromatography.
PIK3CA mutations and predicting the therapeutic effects of neoadjuvant chemotherapy in primary breast cancer
Background: PIK3CA mutations are known to be associated with a reduced pathological complete response (pCR) rate in HER2+ breast cancer, but the relationship between PIK3CA mutations and the therapeutic effects of neoadjuvant chemotherapy in hormone receptor (HR) -positive or HR −/HER2− breast cancer is not clear. We herein analyzed PIK3CA mutations in primary breast cancers of patients who had undergone neoadjuvant chemotherapy.
Clinicopathological evaluation of papillary thyroid microcarcinomas
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Background: Clinicians sometimes encounter papillary thyroid microcarcinomas (PMCs) under 10 mm in diameter that are associated with lymph node metastasis. In this study, we assessed clinicopathological and other risk factors associated with poor prognosis of the patients.
Tidal response in shallow tectonic tremors
Various types of slow earthquakes (e.g., tectonic tremors and slow slip events) have been reported in tectonic zones, especially in the subduction zone. The tidal response of a tremor is considered to be strongly related to the weak friction state of the plate interface, and many studies have reported observational evidence of such correlation between tides and deep tremor activity.
Low-risk papillary microcarcinoma of the thyroid: A review of active surveillance trials
Several clinical issues are present before and during observation for PMC. Here we list the clinical issues that physicians may encounter, along with our comments.The tumor location of PMC is one of the most important issues in deciding whether active surveillance is indicated. Tumors presenting the possibility of TR invasion, RLN invasion or risk of RLN invasion in case of future progression should be immediately operated without observation.
89P Questionnaire survey on patients’ preference for orally disintegrating tablets or granules of S-1 in postoperative adjuvant treatment for breast cancer
Background: No study has investigated patients’ preference for orally disintegrating tablets (OD) or granules (GN) in patients with breast cancer. In a phase III randomized study of adjuvant one-year treatment with S-1 (tegafur/gimeracil/oteracil) for estrogen-receptor positive, HER2-negative breast cancer (POTENT study), we prospectively compared patients’ preference on two types of dosage forms.
Eribulin mesylate may improve the sensitivity of endocrine therapy in metastatic breast cancer
Eribulin mesylate may improve the sensitivity of endocrine therapy in metastatic breast cancer K. Kobayashi1, Y. Ito1, T. Shibayama1, I. Fukada1, N. Ishizuka2, R. Horii3, S. Takahashi4, F. Akiyama5, T. Iwase6 and S.
Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection
Rhinovirus (RV) infection in asthma induces varying degrees of airway inflammation (e.g. neutrophils), but the underlying mechanisms remain unclear. The major goal was to determine the role of genetic variation [e.g. single nucleotide polymorphisms (SNPs)] of Toll-interacting protein (Tollip) in airway epithelial responses to RV in a type 2 cytokine milieu. DNA from blood of asthmatic and normal subjects was genotyped for Tollip SNP rs5743899 AA, AG and GG genotypes.
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