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Articles by Yalan Chen
Growth factor VEGF-B sustains intestinal Tfh cell stemness to restrict Taurinivorans outgrowth and microbiota-driven obesity
Keywords VEGF-B VEGFR-1 T follicular helper cells Tfh cells stemness senescence IgA Taurinivorans obesity Introduction Mucosal immunosurveillance plays an essential role in metabolic regulation, particularly via immunoglobulin A (IgA)-mediated control of the gut microbiota.1,2,3,4,5 This surveillance is executed in large part by IgA, which continuously monitors the intestinal microbiota to maintain gut homeostasis and prevent microbial encroachment that could disrupt host metabolism.1,2,3,4,5...
Bridging physics and biology in acupuncture: flexible multimodal bioelectronics for decoding the deqi microenvironment
Abstract Clinical standardization of acupuncture remains limited by its reliance on empirical tactile feedback and subjective patient sensations, a physiological response collectively termed Deqi. Here, the Deqi microenvironment refers to the local, time-varying tissue domain around the needle in which mechanical deformation, microvascular perfusion, biochemical mediator release and electrophysiological activity are coupled and measurable.
Heritage preservation and sociocultural adaptation among South Asian immigrants in Hong Kong: a perspective through dynamic family language policy
ABSTRACT Through the lens of family language policy (FLP), this qualitative study examines how South Asian immigrant families in Hong Kong navigate the dual imperatives of preserving their cultural and linguistic heritage while adapting to the sociocultural demands of the host society.
SUMOylation activates ECHS1 for adaptive catabolism in lung cancer
Abstract Cellular metabolism dynamically adapts to nutrient fluctuations, yet the regulatory mechanisms underlying this plasticity remain incompletely understood. In particular, the adaptive activation mechanism of enoyl-CoA hydratase short-chain 1 (ECHS1), a key mitochondrial enzyme for fatty acid and amino acid catabolism, is poorly characterized.
Digital Media Engagement and Health Communication: Analyzing YouTube Reactions to a Brain Dead Pregnant Woman Case
SHS Web of Conferences 229, 02004 (2026) Digital Media Engagement and Health Communication: Analyzing YouTube Reactions to a Brain Dead Pregnant Woman Case * Syracuse University, 222 Waverly Ave, Syracuse, United States * Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
High-Dose Biochar Hinders Micro/Nanoplastic-Induced Soil Positive Priming by Reducing Substrate Quality and Microbial Activity
Occurrence, Fate, and Transport of Aquatic and Terrestrial ContaminantsJanuary 23, 2026 Xinghong Cao State Key Laboratory of Regional Environment and Sustainability, School of Environment, Beijing Normal University, Beijing 100875, China Yalan Chen State Key Laboratory of Regional Environment and Sustainability, School of Environment, Beijing Normal University, Beijing 100875, China Yakov Kuzyakov Department of Soil Science of Temperate Ecosystems & Department of Agricultural Soil Science,...
Riverine emission of small plastic particles from Yangtze River into the ocean - Communications Earth & Environment
Abstract Rivers are major pathways for terrigenous plastics to the ocean, yet the spatio-temporal variability of plastic flux remains poorly quantified. Here, we conducted annual field monitoring of plastic particle fluxes in the Yangtze River, accounting for both vertical and horizontal variations in plastic distribution within the estuary. Microplastics were ubiquitous but exhibited spatial and temporal heterogeneity.
Biochar mitigates microplastic‐induced destabilization of soil organic carbon via molecular recalcitrance and microbial process regulation
1 INTRODUCTION Soil organic carbon (SOC) constitutes the largest terrestrial carbon pool, storing 2–3 times the carbon of terrestrial vegetation and the atmosphere (Eswaran et al., 1993). Consequently, even minor changes in its carbon sequestration can significantly affect the global carbon cycle and climate change (Davidson & Janssens, 2006; Paustian et al., 2016).
Construction of vincristine-loaded bimetallic nanoparticles doped zeolite imidazolate frameworks-8 displays promising synergic chemodynamic and photothermal therapy in glioma cancer
Abstract Chemodynamic treatment (CDT) faces obstacles related to low catalytic ion efficacy and reactive oxygen species (ROS) generation. We constructed Z8/Cu@Fe-VC to overcome these challenges. The nanoparticles were developed by incorporating copper into zeolite imidazolate frameworks-8 (Z8) and combining Fe3+ with vincristine (VC). The formation of ROS under an acidic milieu and its photothermal effects were evaluated.
Spatial and Temporal Distribution Characteristics and Value Cognition of Shaanxi’s Hospital Heritage
1. Introduction Following the Council of Europe’s 20th-century Heritage Seminars in Vienna (1989) and Barcelona (1990) [1], diverse heritage typologies, including industrial plants, hospitals, urban settlements, and university campuses, have been progressively integrated into the World Heritage List [2,3]. China responded to these international trends by initiating nationwide conservation efforts for 20th-century architectural heritage in 2008.
High-throughput two-photon volumetric brain imaging in freely moving mice
Abstract Imaging neural activities across large volumes at subcellular resolution without impeding animal behaviors remains difficult. Here we introduce a high-throughput miniature Bessel-beam two-photon microscope capable of imaging calcium dynamics from neurons and dendrites over a volume of 420 × 420 × 80 μm3 during free behavior. We share full description of the microscope and demonstrate calcium imaging of more than 1000 neurons at a time in freely moving mice.
Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses
Abstract T cells rewire their metabolic activities to meet the demand of immune responses, but how to coordinate the immune response by metabolic regulators in activated T cells is unknown. Here, we identified autocrine VEGF-B as a metabolic regulator to control lipid synthesis and maintain the integrity of the mitochondrial inner membrane for the survival of activated T cells.
A Two-Component Polarimetric Target Decomposition Algorithm with Grassland Application
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Monoclonal antibody‐based systematic identification of SUMO1‐modification sites reveals TFII‐I SUMOylation is involved in tumor growth
RESEARCH ARTICLE Yalan Chen, Kexin Liu, and Geqiang Zhang contributed equally to this study. Abstract SUMOylation plays an essential role in diverse physiological and pathological processes. Identification of wild-type SUMO1-modification sites by mass spectrometry is still challenging. In this study, we produced a monoclonal SUMO1C-K antibody recognizing SUMOylated peptides and proposed an efficient streamline for identification of SUMOylation sites.
Effects of microplastics and biochar on soil cadmium availability and wheat plant performance
Abstract Biochar is a promising amendment to promote cadmium (Cd) sorption and fixation in agricultural soil, where microplastics are emerging contaminants in soil. Herein, a greenhouse pot experiment was conducted to elucidate the effects on Cd availability in a soil–plant system by biochar and fresh/aged microplastics application.
Analytical solutions for time-dependent kinematic three-dimensional magnetic reconnection
Time-dependent magnetic field case To simplify Eqs (1)–(4), the curl of the electric field is zero in Eq (2) for a stationary magnetic field, however, we don’t adopt such simplification in our time-dependent magnetic reconnection cases. Instead, the magnetic field configuration and current density are assumed to have the form: (14) (15) The introduction of time-dependent magnetic field makes Eq (7) no longer hold.
Substantial burial of terrestrial microplastics in the Three Gorges Reservoir, China - Communications Earth & Environment
Study area This study focused on two areas around the TGD: the reservoir region (upstream of the dam, covering a catchment area of 1084 km2) and the downstream area of the TGD. The operation of TGD, the world’s largest hydropower project, has brought about significant benefits for hydropower generation, flood control and shipping70. The total length of the dam axis is 2309.47 m, the crest elevation is 185 m, and the designed water level is 175 m.
SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation
Highlights • SENP2 is essential for BAT development • SENP2 deficiency increases Necdin expression to suppress brown adipogenesis • SUMOylation suppresses CREB activity through PP2A-mediated de-phosphorylation • SENP2 de-SUMOylates CREB to suppress Necdin expression Summary Brown adipose tissue (BAT) is a thermogenic organ that maintains body temperature and energy homeostasis. Transcriptional regulation plays an important role in the program of brown adipogenesis.
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