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Yan-Shan Liu

As seen in: BioRxiv, Cell Reports
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Articles

Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing

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By Yan-Shan Liu, Chun-Yan Ren, Yu-Shan He, Lin-Pei Zhang
| Cell Reports Verified
Highlights • Engineered mA3A-based CBEs provide a prototype option for further optimization • Deleting SVR in BE4-mA3A improves its off-target activities and editing accuracy • Chimeric BE4-hA3A-SVR+ shows improved editing efficiency • SVR motif is important in defining CBE intrinsic properties Summary Cytidine deaminase defines the properties of cytosine base editors (CBEs) for C-to-T conversion.
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Multi-tissue transition of A-to-I RNA editing pattern and its regulatory relevance in transcription, splicing, and translation during development

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By Jia-Qi Pan, Xu-Bin Pan, Yan-Shan Liu, Yun-Yun Jin
| BioRxiv
Abstract Previous studies have shown that A-to-I RNA editing can occur in various organs and tissues of normal physiological conditions. However, the dynamics of RNA editing and its functional relevance in multiple tissues and organs during the embryo-to-adult transition in mammals remains to be elucidated.
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