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Articles by Yang Hai
Comparative Study of TCN+GAN and LSTM+CNN Architectures for Time-History Curves Prediction
Submitted: 25 October 2026 You are already at the latest version Predicting the unobserved rear half of an acceleration time-history curve can make automotive safety evaluation more efficient. This study compares two deep-learning models, LSTM+CNN and TCN+GAN, for reconstructing post-impact acceleration signals from their observed front halves.
Biosynthesis of the α-d-mannosidase inhibitor (−)-Swainsonine - Nature Chemical Biology
Abstract (−)-Swainsonine is a polyhydroxylated indolizidine alkaloid with potent inhibitory activity against α-d-mannosidases. Although the genetic basis of its biosynthesis has been established, the biosynthetic mechanism underlying its formation remains poorly understood. Here we report the complete elucidation of the biosynthetic pathway through a combination of in vivo and in vitro reconstitution studies.
Biochemical dissection of a fungal highly reducing polyketide synthase condensing region reveals basis for acyl group selection.
Biochemical dissection of a fungal highly reducing polyketide synthase condensing region reveals basis for acyl group selection. Fungal highly reducing polyketide synthases (hrPKSs) are remarkable multidomain enzymes that catalyse the biosynthesis of a diverse range of structurally complex compounds.
Galloping Performance of Transmission Line System Aeroelastic Model with Rime Through Wind-Tunnel Tests
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Screening and validation of potential biomarkers of immune cells in ch
Back to Journals » Journal of Inflammation Research » Volume 18 Authors Zhang Y , Hai Y, Song B , Xu J, Cao L, Yasen R, Xu W, Zhang J, Hu J Received 5 November 2024 Accepted for publication 7 February 2025 Published 21 February 2025 Volume 2025:18 Pages 2583—2600 DOI https://doi.org/10.2147/JIR.S498017 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Tara Strutt Yang Zhang,1– 4 Yang Hai,1– 3 Bangguo Song,4 Jing...
Biosynthesis of the alpha-D-Mannosidase Inhibitor (-)-Swainsonine
Abstract (-)-Swainsonine is a polyhydroxylated indolizidine alkaloid with potent inhibitory activity against alpha-D-mannosidases. In this work, we successfully reconstituted swainsonine biosynthetic pathway both in vivo and in vitro. Our study unveiled a surprising epimerization mechanism involving an imine reductase (SwnN) and two non-heme iron and a-ketoglutarate-dependent oxygenases (SwnH2 and SwnH1).
Enzymatic Synthesis of Unprotected α,β-Diamino Acids via Direct Asymmetric Mannich Reactions
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Mining the noncanonical terpenome - Nature Chemical Biology
Terpenoids bearing carbon skeletons derived from nonisoprene units are rare and considered noncanonical. Now, a genome-mining study has uncovered previously unknown noncanonical C16 terpenes and their biosynthetic pathways from bacteria. The findings suggest that noncanonical terpenoids are diverse and widespread in nature.
Bayesian linear mixed model with multiple random effects for family-based genetic studies
Introduction Family-based study (e.g., twin study) is one of the most popular designs used in genetic research, and it offers many unique features for risk prediction studies. For example, the relatedness among family members helps capture the predictive effects from unmeasured/unknown polygenic and shared environmental factors, and thus contributes additional information, beyond the measured data, for risk prediction studies (Ruderfer et al., 2010).
Stereoselective Biocatalytic α‐Deuteration of L‐Amino Acids by a Pyridoxal 5’‐Phosphate‐Dependent Mannich Cyclase
Conflict of interest The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Stereoselective Biocatalytic α‐Deuteration of L‐Amino Acids by a Pyridoxal 5’‐Phosphate‐Dependent Mannich Cyclase
Conflict of interest The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Elucidating the molecular programming of a nonlinear non-ribosomal peptide synthetase responsible for fungal siderophore biosynthesis - Nature Communications
Abstract Siderophores belonging to the ferrichrome family are essential for the viability of fungal species and play a key role for virulence of numerous pathogenic fungi. Despite their biological significance, our understanding of how these iron-chelating cyclic hexapeptides are assembled by non-ribosomal peptide synthetase (NRPS) enzymes remains poorly understood, primarily due to the nonlinearity exhibited by the domain architecture.
Obstructive sleep apnea affects the psychological and behavioural development of children-a case-control study
Summary This study aims to investigate the effects of obstructive sleep apnea on paediatric psychological and behavioural abnormalities. A total of 1086 paediatric patients with obstructive sleep apnea and 728 sample snoring controls were enrolled in the study. Patients with obstructive sleep apnea underwent bilateral tonsillectomy plus adenoidectomy or adenoidectomy alone.
Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error
CONFLICT OF INTEREST STATEMENT None. Supporting Information Filename Description bcp15744-sup-0001-Supporting information-BJCP-20230320.docxWord 2007 document , 705 KB DATA S1 Supporting information REFERENCES 1, , , . Bleomycin-induced flagellate erythema after venous malformation sclerosis—case report and brief review. Pediatr Dermatol. 2018; 35(1): e5-e8. doi:10.1111/pde.13297 2, . Medical errors. Dosage nomenclature of bleomycin needs to be standardised to avoid errors. BMJ.
Lactococcus garvieae FUA009, a Novel Intestinal Bacterium Capable of Producing the Bioactive Metabolite Urolithin A from Ellagic Acid
Open AccessArticle by Haoyu Mi 1,2, Shu Liu 1,2,3, Yang Hai 4, Guang Yang 1,2,3, Jing Lu 1,2,3, Fuxiang He 1,2, Yaling Zhao 1,2, Mengjie Xia 1,2, Xiaoyue Hou 1,2,3,5,6,*,† and Yaowei Fang 1,2,5,† 1 Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang 222005, China 2 Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang 222005, China 3 College of Food Science and Engineering, Jiangsu Ocean...
Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l-Pipecolic Acids
Fusaric acid (FA) is a well-known mycotoxin that plays an important role in plant pathology. The biosynthetic gene cluster for FA has been identified, but the biosynthetic pathway remains unclarified. Here, we elucidated the biosynthesis of FA, which features a two-enzyme catalytic cascade, a pyridoxal 5′-phosphate (PLP)-dependent enzyme (Fub7), and a flavin mononucleotide (FMN)-dependent oxidase (Fub9) in synthesizing the picolinic acid scaffold.
Fungal siderophore biosynthesis catalysed by an iterative nonribosomal peptide synthetase
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P-functionalized and O-deficient TiOn/VOm nanoparticles grown on Ni foam as electrode for supercapacitor: epitaxial grown heterojunction and visible-light-driven photoresponse
P-functionalized and O-deficient TiOn/VOm nanoparticles grown on Ni foam as electrode for supercapacitor: epitaxial grown heterojunction and visible-light-driven photoresponse P-TiOn-VOm nanowires were grown on nickel foam (NF) by one-pot hydrothermal and further vapor deposition/phosphorization method. It is found low valence states of titanium oxide and deficient-oxygen coexist in P-TiOn-VOm/NF.
PeerJ - Life and Environment
Conservation Biology, Ecology, Marine Biology, Natural Resource Management, Population Biology
Complete Stereoinversion of l-Tryptophan by a Fungal Single-Module Nonribosomal Peptide Synthetase
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Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI
Abstract LepI is an S-adenosylmethionine (SAM)-dependent pericyclase that catalyses the formation of the 2-pyridone natural product leporin C.
Biosynthesis of Long-Chain N-Acyl Amide by a Truncated Polyketide Synthase-Nonribosomal Peptide Synthetase Hybrid Megasynthase in Fungi
Truncated iterative polyketide synthase–nonribosomal peptide synthetase (PKS-NRPS) megasynthases in which only the C domain is present are widespread in fungi, yet nearly all members have unknown functions. Bioinformatics analysis showed that the C domains of such PKS-C enzymes are noncanonical due to substitution at the second histidine in the active site HHxxxDG motif.
Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation
Hydroalkoxylation is a powerful and efficient method of forming C–O bonds and cyclic ethers in synthetic chemistry. In studying the biosynthesis of the fungal natural product herqueinone, we identified an enzyme that can perform an intramolecular enantioselective hydroalkoxylation reaction. PhnH catalyzes the addition of a phenol to the terminal olefin of a reverse prenyl group to give a dihydrobenzofuran product.
Nouveau plongeon des bourses chinoises
L'indice CSI300 des plus grandes valeurs cotées à Shanghaï et Shenzhen a chuté de 8,6 % à 3818,73 points, et l'indice Composite de Shanghai de 8,5 % à 3725,56 points. À Hong Kong, l'indice Hang Seng a reculé de 3,1 %, sa plus forte baisse quotidienne en près de trois semaines.
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