Yann Roussel

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Verasztó C, Roussel Y, Kanari L, Piluso S, Markram H, Keller D (2026) A multimodal spatial atlas of transcriptomic, morphological, and electrophysiological cell type densities in the mouse brain. PLoS Comput Biol 22(3): e1014106.

Abstract The cerebral microvasculature forms a dense network of interconnected blood vessels where flow is modulated partly by astrocytes. Increased neuronal activity stimulates astrocytes to release vasoactive substances at the endfeet, altering the diameters of connected vessels. Our study simulated the coupling between blood flow variations and vessel diameter changes driven by astrocytic activity in the rat somatosensory cortex.

Validation of the cross-dataset clustering pipeline We submitted our pipeline to two types of validations. First, a validation for molecular type prediction and second, a validation for cross-species prediction. The first kind of validation means that we want to test how good our approach is to predict the molecular ID of a neuron solely based on the available me-features. Since we had no information about the molecular ID of BBP me-models we restricted ourselves to the AIBS dataset only.