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Development of a risk stratification tool for rapidly progressive diabetic retinopathy in type 2 diabetes
Abstract Background: The progression of rapidly progressive diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) is characterized by substantial inter-individual variability.
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
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Abstract Activation of G protein-coupled receptors (GPCRs) by extracellular ligands is crucial for cellular communication and modulates numerous physiological processes. Despite sharing highly similar orthosteric binding sites, catecholamine GPCRs exhibit exquisite selectivity for their native agonists, even among nearly identical chemical messengers. However, the molecular basis and evolution of receptor selectivity remain poorly understood.
By Nour Aldin Kahlous, Maiju K. Rinne, Xin Zhang, Yanying Li, Yue Chen, Kaixuan Gao, Christina A Bergqvist, Yi Wang, Alejandro Díaz-Holguín, Tore Bengtsson, Volker M Lauschke, Jyrki P. Kukkonen, Lucie Delemotte, Shane Wright, Xiangyu Liu, Dan Larhammar, Jens Carlsson, Aikaterini Motso, Hongda Sheng, Philip Ullmann
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Nature
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Machine-learning for age-related macular degeneration using multimodal fundus data
Abstract Objective: To develop an integrated model that combines multimodal fundus image features for accurately predicting the individualized risk of progression from early to late stages of age-related macular degeneration (AMD). Methods: A retrospective analysis was conducted on the data of 324 patients with AMD. The patients were randomly divided into a training set (n = 227) and a validation set (n = 97) at a ratio of 7:3.
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