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Yao-Ying Ma

As seen in: Nature, Biological Psychiatry
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Articles

Contrasting roles of secondary motor cortex projections to the dorsolateral and dorsomedial striatum in incubation of cocaine-seeking

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By Donald Huang, Yingying Chen, Changyong Guo, Yao-Ying Ma, Víctor Gómez-Pineda
| Nature Verified
Abstract Cocaine use disorder is characterized by persistent relapse vulnerability, which escalates with prolonged withdrawal. Corticostriatal circuits are key substrates for relapse, yet the role of the secondary motor cortex (M2) and its distinct projections to the dorsolateral striatum (DLS) and dorsomedial striatum (DMS) remains poorly understood.
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Downregulation of Small Conductance Potassium Channels in Cortical Pyramidal Neurons of the Supplementary Motor Cortex Underlies High Cocaine Seeking Behaviors

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By Donald Huang, Yao-Ying Ma
| Biological Psychiatry Verified
Key words cocaine intravenous self-administration cocaine seeking supplementary motor cortex cortical pyramidal neuron small conductance potassium channel Get full text access Log in, subscribe or purchase for full access. REFERENCES 1. Substance Abuse and Mental Health Services Administration Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health Substance Abuse and Mental Health Services. 2019; 2. Kariisa, M. ∙ Seth, P.
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Epac2 activation drives calcium permeable-AMPA receptor accumulation, fueling the incubation of cocaine craving - Neuropsychopharmacology

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By Changyong Guo, Yao-Ying Ma
| Nature Verified
Cocaine addiction is a chronic relapsing disorder. Relapse vulnerability, which persists even after prolonged abstinence and is often triggered by environmental cues associated with drug use, is a major challenge in treating addiction. One potential contributor to relapse is a phenomenon termed incubation of craving, the progressive increase in drug-seeking behavior during abstinence [1].
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