Yashiro Motooka

CPA cyclophosphamide DAPI 4′,6-diamidino-2-phenylindole DEGs differentially expressed genes DMSO dimethyl sulfoxide DSB double-strand break Foxo3a Forkhead Box O3a FSHR follicle-stimulating hormone receptor GCs granulosa cells GSEA gene set enrichment analysis HBOC hereditary breast and ovarian cancer syndrome MAPK mitogen-activated protein kinase mTOR mechanistic target of rapamycin MUT mutant [Brca1(L63/+)] OLA olaparib PARP poly (adenosine diphosphate-ribose) polymerase PI3K...

Abstract Significance: The significance of ferroptosis in cancer therapeutics has now been unveiled. Specific ferroptosis inducers are expected as a promising strategy for cancer treatment, especially in cancers with epithelial mesenchymal transition and possibly in cancers with activated Hippo signaling pathways, both of which cause resistance to traditional chemotherapy but tend to show ferroptosis susceptibility.