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Articles by Yeda Wu
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking - Nature Communications
Abstract Strabismus is a common pediatric eye misalignment and has complex genetic and environmental causes. Previous genome-wide association studies (GWAS) encountered difficulties in identifying strabismus risk variants due to heterogeneity and small samples. We performed large meta-analyses of 11 European-ancestry GWAS (7 sources), analysing broad strabismus (20,464 cases, 954,921 controls) and subtypes (esotropia/exotropia).
Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma - Nature Communications
Abstract Primary open-angle glaucoma typically presents as two subtypes. This study aimed to elucidate the shared and distinct genetic architectures of normal-tension (NTG) and high-tension glaucoma (HTG), motivated by the need to develop intraocular pressure (IOP)-independent drug targets for the disease. We conducted a comprehensive multi-ethnic meta-analysis, prioritized variants based on functional annotation, and explored drug-gene interactions.
Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes - Nature Communications
Abstract The rapid global distribution of COVID-19 vaccines, with over a billion doses administered, has been unprecedented. However, in comparison to most identified clinical determinants, the implications of individual genetic factors on antibody responses post-COVID-19 vaccination for breakthrough outcomes remain elusive.
Uncovering the complex relationship between balding, testosterone and skin cancers in men - Nature Communications
Abstract Male-pattern baldness (MPB) is related to dysregulation of androgens such as testosterone. A previously observed relationship between MPB and skin cancer may be due to greater exposure to ultraviolet radiation or indicate a role for androgenic pathways in the pathogenesis of skin cancers.
150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility
Highlights • Diverticular disease (DivD) GWAS identifies 150 risk variants in ∼724,000 individuals • The derived polygenic score significantly predicts DivD risk with AUC of 0.69 • Potential DivD mechanisms: colon structure, gut motility, gastrointestinal mucus, and ionic homeostasis • Prioritized gene for DivD encodes drug target for IBS, a commonly comorbid disorder Summary We conducted a genome-wide association study (GWAS) analysis of diverticular disease (DivD) of intestine within...
Course constructions: A case-base of forensic toxicology
Publication HistoryPublished online: June 28, 2017Accepted: June 28, 2017; Received in revised form: April 6, 2017; Received: December 25, 2016;
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