Yeonsun Hong

Keywords pancreatic ductal adenocarcinoma immune evasion antigen presentation Dec2 cancer dormancy circadian rhythm sTRA mouse model resectable PDAC Introduction Metastatic recurrence following surgery with curative intent is a major clinical problem in oncology. Latent recurrences arise from disseminating tumor cells (DTCs) that are occult at the time of surgery and remain dormant for years before reactivating to form tumors.

Abstract Many cancer patients not responding to current immunotherapies fail to produce tumor-specific T cells for various reasons, such as a lack of recognition of cancer cells as foreign. Here, we suggest a previously unidentified method for xenogenizing (turning self to non-self) tumors by using fusogenic exosomes to introduce fusogenic viral antigens (VSV-G) onto the tumor cell surface.

As a first step in testing our combined treatment strategy, we investigated whether blockade of ROCK enhances engulfment of cancer cells by phagocytes. Macrophages and DCs were differentiated from bone marrow cells, as assessed by flow cytometry for F4/80 (macrophages) and CD11c (DCs) expression on the cell surface (Supplementary Fig. 1).