Yi-Shuan Li

Abstract During endoderm formation, cell identity and tissue morphogenesis are tightly controlled by cell-intrinsic and cell-extrinsic factors such as biochemical and physical inputs. While the effects of biochemical factors are well studied, the physical cues that regulate cell division and differentiation are poorly understood.

Highlights Atherosclerosis is a chronic inflammatory disease, with endothelial dysfunction and macrophage infiltration. MicroRNA (miR)-92a is significantly enriched in endothelial cells and circulation under atherogenic conditions. Endothelial miR-92a is transported to macrophages mainly through extracellular vesicles. Enriched intravesicular miR-92a enhances macrophage inflammatory responses, lipoprotein uptake, and confines macrophage migration.

Background and Purpose—Endovascular thrombectomy has shown promise for the treatment of acute strokes resulting from large-vessel occlusion. Reperfusion-related injury may contribute to the observed decoupling of angiographic and clinical outcomes. Iatrogenic disruption of the endothelium during thrombectomy is potentially a key mediator of this process that requires further study.