Yi-Zhen Wu on Muck Rack

Yi-Zhen Wu

As seen in: Nature
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Articles

O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling

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By Alice A Lin, Neng-Yu Lin, Marco Keller, William Burton, Chi-Yuan Yao, Nicole Urban, Ya-Wen Liu, Franz Bracher, Antony Galione, Hao-Jen Hsu, Cheng-Chang Chen, Ramona Schütz, Yi-Zhen Wu, Novelyn Putri Kinanti, Ching-Ying Kuo
| Nature
Abstract Two-pore channel 2 (TPC2) is a lysosomal cation channel involved in calcium and sodium signaling and membrane remodeling. Its dysfunction has been linked to diseases including viral infections, neurodegenerative disorders, and cancer. Here, we identify mucin-type O-linked glycosylation at two conserved luminal residues of TPC2, Ser612 and Ser613, as a structural gating brake.
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