William Burton

Abstract Two-pore channel 2 (TPC2) is a lysosomal cation channel involved in calcium and sodium signaling and membrane remodeling. Its dysfunction has been linked to diseases including viral infections, neurodegenerative disorders, and cancer. Here, we identify mucin-type O-linked glycosylation at two conserved luminal residues of TPC2, Ser612 and Ser613, as a structural gating brake.

As we draw towards financial year end, it’s a good time to consider making personal super contributions. While anyone who wants to build their super balance should add to it when they can, there are people who might benefit from it more than others. For example, if you are on a high tax bracket and trying to bring down your taxable income you may like to consider about voluntary contributions.

If you’ve ever wondered about the difference between the Medicare Levy, the Medicare Levy Surcharge, private health insurance, and Lifetime Health Cover loading, you’re not alone. It’s one of those areas of finance that sounds complicated at first, but once you break it down, it’s actually pretty straightforward and understanding it can make a big difference to your wallet. Australia’s healthcare system is one of the world’s best, and it’s funded largely through the Medicare Levy.