Yichao Bao

Abstract Transposable elements (TEs) are reactivated in tumors and serve as significant contributors to tumor transcriptomic complexity and heterogeneity. However, their repetitive nature and diverse transcriptional forms have hindered efforts to characterize TE-derived transcripts independent of host gene contexts.

Study population This study retrospectively reviewed 6896 consecutive patients at FUSCC from January 2011 to December 2015. The inclusion criteria were as follows: 18–80 years old; pathologically confirmed primary colorectal adenocarcinoma, mucinous adenocarcinoma, or signet-ring cell carcinoma; stage II according to the 8th edition of the AJCC/UICC TNM staging system; and receiving radical resection of the primary tumor.

LIN28B-TST Is Produced by Alternative Transcription Initiation with a Strong Promoter   Demethylation of the LIN28B-TST Promoter Is Associated with Its Expression   LIN28B-TST Encodes a Protein Isoform with Additional N-Terminal Amino Acids and Is Critical for Cancer Cell Proliferation and Tumorigenesis In this study, we provide a mechanism of LIN28B activation through alternative transcription initiation and epigenetic alteration.