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Yidi WANG

As seen in: Nature, Frontiers, Emerald Publishing, Thermal Processing Magazine

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Articles

p53 hotspot mutants attenuate CTL-mediated tumor cell killing through a novel ALKBH5-YTHDF3-PD-L1 pathway

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By Zhuan Ju, Xiang Zhang, Wenjie Zuo, Lu Zhang, Xin Fan, Chenxing Zhang, Xiaofang Zhang, Xiao Jun Zhang, Yidi WANG, Ying Xing, Baile Zuo, Angang Yang, Rui Zhang, Huilong Yin
| Nature Verified
Abstract TP53 is a well-documented tumor suppressor gene frequently mutated in malignancies. It has been demonstrated that the gain-of-function (GOF) mutation of p53 promotes the development and progression of cancers; however, its extrinsic oncogenic mechanisms are still poorly understood. Herein, we found that the oncogenic effect of mutant p53 in vivo is dependent on the tumor immune microenvironment.
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Anlotinib combined with neoadjuvant chemotherapy for HR+/HER2− breast cancer (ACNTBC): a prospective, single-arm, single-center phase II clinical study with real-world validation

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By Jiajun Ding, Huimin Meng, Yidi WANG, Mengxuan Li, He Chen, Cong Fan, Shuai Wang, Liying Zhang, Lei Shang, Jing Kong, Jing Fan, Ting Wang, Haoyi Zi
| Nature Verified
Abstract Despite being an option for high-risk or inoperable cases, existing neoadjuvant therapies for hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) breast cancer yield suboptimal pathological responses, necessitating novel strategies. This prospective, phase II ACNTBC trial (NCT05558722) investigated the efficacy and safety of combining anlotinib with chemotherapy as a neoadjuvant treatment for HR+/HER2− breast cancer.
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Heat-treatment effects on the properties of TI made with cold spraying additive manufacturing

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By Yidi WANG, Jiqiang Wang, Zhipo Zhao
| Thermal Processing Magazine Verified
Cold spraying additive manufacturing (CSAM) Ti exhibits minimal plasticity, posing a significant challenge to its broader application. Heat treatment is recognized as a potent strategy to enhance the mechanical properties of additive manufacturing parts. However, prior investigations have struggled to discern the genuine impact of heat treatment on CSAM Ti due to the high porosity in initial deposits. This study addresses this gap by fabricating CSAM Ti deposits with a low porosity of 2.76%.
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