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Yigen Li

As seen in: Nature, Wiley Online Library, Cell Press
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Articles by Yigen Li

SETD2 is a novel and druggable dependency in IMiD/CELMoD resistant multiple myeloma models

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By Sarah Bird, Marco P. Licciardello, Mara Mandelia, Enze Liu, James Smith, Amy Wilson, Shannon Martin, Yigen Li, Fernando J. Sialana, Brian Walker, Paul Clarke Verified, Charlotte Pawlyn, Yakinthi Chrisochoidou, Jack Cheung
| Nature Verified
SETD2 is a histone methyltransferase and is the only enzyme known to be capable of trimethylation of histone 3 lysine 36 (H3K36me2 → H3K36me3). SETD2 can also methylate non-histone proteins and is important in transcriptional regulation, RNA splicing, DNA damage repair and B cell development and differentiation [1, 2].
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CREB1 activation promotes human papillomavirus oncogene expression and cervical cancer cell transformation

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By Yigen Li, Molly Patterson, Ethan Morgan, Christopher W Wasson
| Wiley Online Library Verified
1 INTRODUCTION Human papillomaviruses (HPV) infection can result in cervical intraepithelial neoplasia (CIN), which left untreated may ultimately progress to cervical cancer, a leading cause of death among women.1, 2 HPV DNA is detected in more than 95% of cervical cancers, and the high-risk (HR)-HPVs, particularly HPV16 and HPV18, are responsible for >70% of invasive cervical cancers.3 In addition, HR-HPVs are also associated with head and neck,4 vulvar,5 anal,6 and penile cancers.7 E6 and...
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Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

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By Katherine Bridge, Kunal Shah, Yigen Li, Daniel E. Foxler
| Cell Press Verified
LIMD1 Is Critical for the Interaction of AGO2 with TNRC6A and DDX6 LIMD1 Interacts with AGO2 and TNRC6A via Specific Domains Akt3-Mediated Phosphorylation of S387 in the AGO2 L2 Domain Is Necessary for Interaction with LIMD1 LIMD1 Acts as a Molecular Clamp to Secure Phospho-AGO2 and TNRC6A Together within miRISC We next examined the binding partners and function of LIMD1 in miRISC in more detail to shed light on why loss of LIMD1 appeared to render AGO2 unable to contribute to silencing of...
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