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Yijuang Chern

As seen in: Nature, Frontiers, MDPI, Journal of Biomedical Science
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Articles

Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells - Nature Communications

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By Yi-Chuan Wang, Ming-Han Yang, Jia-Ying Su, Gerlinde Wernig, Ping-Chih Ho, Yih-Leong Chang, Yao-Ming Chang, Chia-Wei Li, Tai-Ming Ko, Ya-Jen Chang, Yijuang Chern
| Nature Verified
Abstract In eukaryotic cells, reactive oxygen species (ROS) serve as crucial signaling components. ROS are potentially toxic, so constant adjustments are needed to maintain cellular health. Here we describe a single-cell, mass cytometry-based method that we call signaling network under redox stress profiling (SN-ROP) to monitor dynamic changes in redox-related pathways during redox stress.
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The Impact of Dysregulated microRNA Biogenesis Machinery and microRNA Sorting on Neurodegenerative Diseases

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By Yu-Ting Weng, Yao-Ming Chang, Yijuang Chern
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Yu-Ting Weng , Yao-Ming Chang and Yijuang Chern * Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan * Author to whom correspondence should be addressed. Int. J. Mol. Sci.
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Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases

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By Yijuang Chern, Sung Lee
| Frontiers
Introduction The polyglutamine (polyQ) diseases are a group of inherited neurodegenerative diseases that are caused by the abnormal expansion of a CAG triplet repeat (above 35–40 repeats) in the coding region within the causative gene of each disease. This expanded CAG repeat is translated into an expanded polyQ stretch in the resultant protein product (Orr and Zoghbi, 2007).
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