Abstract Wound management remains a significant clinical challenge due to bacterial infection, oxidative stress, and inflammation. To address these issues, we developed a multifunctional hydrogel, NO-GM/Fle@FD, by combining gelatin methacryloyl (GelMA), Pluronic F127 diacrylate (F127DA), the nitric oxide (NO) donor S-nitrosoglutathione (GSNO), and the antibiotic fleroxacin (Fle).