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Yin-Chiu Lo on Muck Rack

Yin-Chiu Lo

As seen in: The Journal of Biological Chemistry, The Journal of Immunology
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Articles

Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy

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By Wan-Ting Tsai, Yin-Chiu Lo, Ming-Sian Wu, Chia-Yang Li
| The Journal of Biological Chemistry Verified
Innate immune responses are important for pathogen elimination and adaptive immune response activation. However, excess inflammation may contribute to immunopathology and disease progression (e.g. inflammation-associated hepatocellular carcinoma). Immune modulation resulting from pattern recognition receptor-induced responses is a potential strategy for controlling immunopathology and related diseases.
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Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy

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By Yin-Chiu Lo, Wan-Ting Tsai, Ming-Sian Wu, Chia-Yang Li
| The Journal of Biological Chemistry Verified
Author contributions: WTT, YCL and MSW conducted most of the experiments. CYL initiated the compound screening platform. YPK, YHL, YT and KCC performed experiments for candidate compound validation. CHY and JCL conducted PMI synthesis. THC, LCH and JTH participated in experimental design, data interpretation and manuscript preparation with GYY. Innate immune responses are important for pathogen elimination and adaptive immune response activation.
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Roles of innate immune regulator TAPE in RIG-I signaling and antiviral defenses

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By Kuan Ru Chen, Chia-Yu Yang, Chun-Yang Lin, Wan-Ying Lin, Yin-Chiu Lo
| The Journal of Immunology Verified
Pattern-recognition receptors detect pathogen-associated molecular patterns to trigger downstream pathways leading to type I IFN and inflammatory cytokines production to defend pathogen infection. RIG-I-like receptors (RLRs) are key cytosolic sensors for recognizing viral RNA to trigger antiviral immunity. The underlying mechanisms linking RLR-mediated viral recognition to antiviral immunity remain to be further explored.
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