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The KAT8-CDK1 K33 acetylation axis drives doxorubicin resistance by suppressing ferroptosis and apoptosis in breast cancer
Abstract Doxorubicin (Dox) resistance severely limits therapeutic efficacy in breast cancer, yet the epigenetic mechanisms linking cell-cycle control to therapy-induced cell death remain unclear. Here, we identify the histone acetyltransferase KAT8 as a critical driver of Dox resistance. Transcriptomic analysis of neoadjuvant cohorts revealed elevated KAT8 expression in residual disease (RD) tumors, which was validated in an independent cohort of 95 patients.
Visible Light-Induced Vinyl Radical Generation/Isomerization/Radical Coupling of Tetrasubstituted Vinyl Chlorides and Thiols Via Electron Donor–Acceptor Complexes
Zhiyong, Gao Yin, Liu Xuran, Liu Guanting, Zheng Yajun, Zhang Yuanqi, Zheng Jia, Hu Weigao, Visible Light-Induced Vinyl Radical Generation/Isomerization/Radical Coupling of Tetrasubstituted Vinyl Chlorides and Thiols Via Electron Donor–Acceptor Complexes, Advanced Synthesis & Catalysis2026, 0, e70565. Li https://doi.org/10.1002/adsc.70565 Conflicts of Interest The authors declare no conflicts of interest.
Strongly Coupled Ni12P5@NCNT Bifunctional Electrocatalysts for Efficient CO2 Reduction and Glycerol Oxidation
Cite Jump to ExpandCollapse ArticleDecember 30, 2025 Strongly Coupled Ni12P5@NCNT Bifunctional Electrocatalysts for Efficient CO2 Reduction and Glycerol Oxidation Click to copy article linkArticle link copied! Jiangquan Lv Jiangquan Lv College of Electronics and Information Science and Organic Optoelectronics Engineering Research Center of Fujian’s Universities, Fujian Jiangxia University, Fuzhou 350100, China Yin Gao Yin Gao School of Materials and Chemistry,Anhui Agricultural University,...
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