Yin He

Background: Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis. Microglia are key immune cells in the GBM tumor microenvironment (TME), yet their subtype-specific impact, particularly inflammatory microglia, remains poorly understood. Methods: We analyzed single-cell RNA sequencing data to characterize inflammatory microglia patterns in GBM. Patient subgroups were compared for clinical features, molecular profiles, and predicted immunotherapy responses.

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Publicly available datasets were analyzed in this study. These data can be accessed at the following sources: GDC Data Portal and the NCBI Gene Expression Omnibus (GEO). Supporting Information Filename Description iub70104-sup-0001-FigureS1.pdfPDF document, 44 KB Figure S1: Bubble plot showing the strength of outgoing (X-axis) and incoming (Y-axis) signaling pathways.

Introduction Ascites refers to the abnormal accumulation of fluid in the abdominal cavity, Common causes of ascites include cirrhotic portal hypertension, which accounts for the majority of cases, malignant tumors, heart failure, spontaneous bacterial peritonitis, and tuberculous peritonitis (1, 2). POEMS syndrome is a rare cause of ascites, often presenting with polyneuropathy, organomegaly, endocrine abnormalities, monoclonal gammopathy, and skin lesions.