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Yin-jun Ma

As seen in: The Journal of Biological Chemistry
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Articles

The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα

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By Xin Dou, Wei-yu Zhou, Yin-jun Ma, Qi-Qi Yang
| The Journal of Biological Chemistry Verified
Uncontrolled gluconeogenesis results in elevated hepatic glucose production in type 2 diabetes (T2D). The small ubiquitin-related modifier (SUMO)-specific protease 2 (SENP2) is known to catalyze deSUMOylation of target proteins, with broad effects on cell growth, signal transduction, and developmental processes. However, the role of SENP2 in hepatic gluconeogenesis and the occurrence of T2D remain unknown.
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