Yin Lv
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Trajectory changes of symptom clusters in patients with concurrent chemoradiotherapy for cervical cancer: a prospective longitudinal study
Abstract Objective: To identify the trajectory changes of symptom clusters during concurrent chemoradiotherapy in cervical cancer patients and to explore the heterogeneity of symptom experience among different patients. Methods: From June 2024 to June 2025, 150 patients with cervical cancer undergoing concurrent chemoradiotherapy at a tertiary-level hospital in Anhui Province were selected as the study subjects.
pH/GSH Dual-responsive Fe-based MOF drug carrier for ferroptosis-glycolysis synergistic therapy
pH/GSH Dual-responsive Fe-based MOF drug carrier for ferroptosis-glycolysis synergistic therapy Ferroptosis, a recently recognized form of non-classical programmed cell death (PCD), leads to impaired cellular structure and integrity due to the accumulation of lipid peroxidation products (LPO). However, single treatment ferroptosis often fails to achieve optimal tumor treatment outcome.
ROS-responsive polymeric micelles with aggregation-induced emission effects for drug delivery and cellular imaging
ROS-responsive polymeric micelles with aggregation-induced emission effects for drug delivery and cellular imaging Traditional chemotherapy faces challenges related to limited drug efficacy and adverse reactions. Intelligent nanocarrier drug delivery systems (INDDS) promise improved treatment outcomes with reduced toxicity. However, several clinical challenges persist in achieving rapid drug release and real-time monitoring.
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