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IGFBP3 As a Potential Biomarker and Therapeutic Target in Hepatocellular Carcinoma: A Multi-Cohort Analysis
1 Introduction Hepatocellular carcinoma (HCC) is a significant global health concern owing to its aggressive nature and poor prognosis [1]. It is the fourth leading cause of cancer-related mortality worldwide, with approximately 905,700 new cases and 830,200 deaths reported annually [2]. Key risk factors for HCC include chronic HBV/HCV infection, metabolic disorders (e.g., NAFLD and diabetes), excessive alcohol consumption, and exposure to environmental toxins [3-5].
Greek lawmaker highlights respect and win-win cooperation as pillars of China-EU relations
Greek lawmaker highlights respect and win-win cooperation as pillars of China-EU relations As 2025 marks the 50th anniversary of diplomatic relations between China and the European Union (EU), Dora Bakoyannis, chair of the Standing Committee on National Defense and Foreign Affairs of Greece's Hellenic Parliament, emphasized the importance of mutual respect and win-win cooperation in an exclusive interview with People's Daily Online during her recent visit to China.
Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening
Highlights • Nynrin is highly expressed in HSCs under a steady and stressful state • Nynrin deficiency compromises HSC maintenance • Nynrin inhibits mPTP opening by transcriptionally repressing Ppif expression • Overexpression of Nynrin diminishes radiation-induced lethality in HSCs Summary Mitochondria are key regulators of hematopoietic stem cell (HSC) homeostasis.
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