Yin Zhao
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TIM3-targeted delivery of venetoclax overcomes drug resistance and reinvigorates NK cell activity in acute myeloid leukemia
Abstract Acute myeloid leukemia (AML) remains challenging, especially for older or unfit individuals who develop resistance to venetoclax (VEN)-based regimens. Although TIM3 represents a promising AML target, clinical blockade has yielded suboptimal outcomes. Here, we develop VINCENT (VEN-integrated natural killer cell engager targeting TIM3), a therapeutic platform combining anti-CD16 and anti-TIM3 antibodies with nanoformulated VEN.
Ultrathin Polymer-Based Composite Electrolyte Compatible with 4.7 V Cathode for High-Voltage Li-Metal Batteries
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description adfm76948-sup-0001-SuppMat.docx13.6 MB Supporting File: adfm76948-sup-0001-SuppMat.docx.
Effects of enteral immunonutrition enriched with multiple immunonutrients on clinical outcomes of patients who underwent gastric cancer surgery: a systematic review and meta-analysis
Abstract Objective: To evaluate the clinical efficacy of enteral immunonutrition (EIN) compared to standard enteral nutrition (EN) in patients undergoing gastric cancer surgery. Methods: We searched major databases for randomized controlled trials (RCTs) published up to December 2025. Nineteen RCTs involving 1,653 patients were included. Outcomes assessed included infectious and total complications, length of hospital stay (LOS), gastrointestinal tolerance, and immune-inflammatory markers.
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