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Yina Gao on Muck Rack

Yina Gao

As seen in: Nature, Wiley Online Library, BioRxiv, Cell Press
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Articles

Octameric dGTPase assemblies mediate broad anti-phage defense

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By Miao Shi, PeiPei Li, Quanjin Li, Chao Ning, Sen Yin, Yina Gao, Yong Huei Wang, Jingyu Li, Zhaolong Li, Songqing Liu, Dong Li, Changwei Wei, Ang Gao
| Nature Verified
Abstract Deoxyguanosine triphosphatases (dGTPases) are nucleotide-depleting enzymes known to play a role in antiviral defense. While their enzymatic mechanism is established, the structural and functional diversity of dGTPases remains poorly understood. Here, we report a systematic analysis of dGTPase homologs across bacteria, archaea, and eukaryotes, revealing their widespread distribution and association with diverse immune-related domains.
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2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity

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By Yina Gao, Zhaolong Li, Yufei Zhou, Weimin Li, Quanjin Li, Jingge Wang, Miao Shi, Feng Ye, Chunqiu Zhao, Songqing Liu, Qiuyao Jiang, Yun Zhu, Fei Sun, Ang Gao, Pu Gao
| Cell Press Verified
Keywords CBASS cGAS CD-NTase cGAMP SAVED antiphage cell death membrane disruption membrane shearing Get full text access Log in, subscribe or purchase for full access. References 1. Whiteley, A.T. ∙ Eaglesham, J.B. ∙ de Oliveira Mann, C.C. ... Bacterial cGAS-like enzymes synthesize diverse nucleotide signals Nature. 2019; 567:194-199 2. Cohen, D. ∙ Melamed, S. ∙ Millman, A. ... Cyclic GMP–AMP signalling protects bacteria against viral infection Nature. 2019; 574:691-695 3. Millman, A. ∙ Melamed, S.
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Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses

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By Miao Shi, Tao Jiang, Mengfan Zhang, Quanjin Li, Kexin Liu, Ni Lin, Xinlu Wang, Amin Jiang, Yina Gao, Yong Wang, Songqing Liu, Liguo Zhang, Dong Li, Pu Gao
| Cell Press Verified
Keywords ZCCHC3 cGAS cGAMP STING RIG-I MDA5 MAVS nucleic-acid sensing phase separation structural biology Introduction The host innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through germline-encoded pattern recognition receptors (PRRs).
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